Figure 2

Lesion scores of bladder tissue from F344 rats inoculated with U. parvum. Lesion score analysis was done prior to grouping each sample into a clinical profile (Panels A, B, and C) or inoculum dose groups (Panel D). Data is a summation of 5 separate experiments. In panels A, B, and C, nonparametric lesion scores were grouped according to the clinical profile and analyzed by Kruskall- Wallis test (Control, n = 6; Negative, n = 36; UTI, n = 11; Struvite, n = 10). Panel D are the results of an inflammatory cell type lesion score analysis performed on bladder tissues from animals in the Negative group. Scoring for cell types that comprised the inflammatory infiltrate was: 1 for primarily mononuclear cells (lymphocytes, plasma cells and macrophages), 2 for mononuclear cells and neutrophils, and 3 for mononuclear cells, neutrophils and fibrous infiltrates. Data is a summation of 5 separate experiments. Nonparametric lesion scores were grouped according to the inoculum dose of U. parvum. Raw lesion scores were analyzed by Kruskall- Wallis test (n = 10 for log 1 CFU, n = 11 for log 3 CFU, n = 8 for log 5 CFU, n = 5 for log 7 CFU, and n = 3 for log 9 CFU). Values in all graphs represent raw lesion scores for each biological replicate. Horizontal bars demarcate the median value for each clinical profile group.