Electron micrographs of the proximal tubule. Control animal showed a normal tubule and normal appearance of mitochodria (A). Loss of polarity of mitochondria and increased perinuclear clear space occurred in the endotoxemic kidney (B). Amrinone infusion restored mitochondrial integrity and intracellular edema (C). Scale Bar = 5 μm. Nu, nucleus; M, mitochondria; Ly, lysosome.