Time-courses of the outbreak with adaptive treatment strategy. The effect of changing treatment level during the outbreak on the time course of clinical infections with R
0 = 2. Simulations were seeded with an initial treatment level 25%, and then changed to 80% at: (a) day 40 with stockpile of size 8.5% (relative to S
0); (b) day 40 with stockpile of size 12% (relative to S
0); (c) day 40 with adequate drug supply; (d) day 50 with adequate drug supply. Solid curves show the time courses for the ratio of the clinical infections to S
0 caused by all strains, and dashed curves represent those of only resistant infections.