Final size of infections with adaptive treatment strategy. The effect of changing treatment level during the outbreak on the total number of clinical infections caused by all strains, with various sizes of stockpile and R
0 = 2. Simulations were seeded with an initial treatment level of: (a) 0% without resistance; (b) 0% with resistance; (c) 25% without resistance; (d) 25% with resistance, and then changed to 80% at the time displayed on the vertical axis (corresponding to the time-course of the outbreak). The color bars illustrate the ratio of the total number of clinical infection to S
0 due to all strains. Run-out occurs in the regions consisting of the origin and delimited by the solid curves.