Direct susceptibility testing for multi drug resistant tuberculosis: A meta-analysis

BMC Infectious Diseases

Table 3 Spearman correlation coefficient Logit (sensitivity) vs Logit (1- specificity)

Test	Rifampicin		Isoniazid
	Spearman correlation coefficient	p-value	Spearman correlation coefficient	p-value
Nitrate Reductase Assay	0.400	0.600	1.000	0.000
MODS	0.086	0.872	0.143	0.787
Genotype^® MTBDR	0.500	0.667	1.000	0.000
Genotype^® MTBDRplus	-0.200	0.747	-0.100	0.873

MODS = Microscopic Observation Drug Susceptibility. Note: A strong positive Spearman correlation coefficient between the logit of sensitivity and logit of 1-specificity suggests threshold/cutoff effect [27]. Since pooling sensitivity and specificity is more reliable in the absence of a threshold effect the NRA and the Genotype^® MTBDR assays should be primarily judged based on their areas under sROC, while the other tests can be reliably judged based on their pooled values.

ISSN: 1471-2334