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Table 3 Spearman correlation coefficient Logit (sensitivity) vs Logit (1- specificity)

From: Direct susceptibility testing for multi drug resistant tuberculosis: A meta-analysis

Test Rifampicin Isoniazid
  Spearman correlation coefficient p-value Spearman correlation coefficient p-value
Nitrate Reductase Assay 0.400 0.600 1.000 0.000
MODS 0.086 0.872 0.143 0.787
Genotype® MTBDR 0.500 0.667 1.000 0.000
Genotype® MTBDRplus -0.200 0.747 -0.100 0.873
  1. MODS = Microscopic Observation Drug Susceptibility. Note: A strong positive Spearman correlation coefficient between the logit of sensitivity and logit of 1-specificity suggests threshold/cutoff effect [27]. Since pooling sensitivity and specificity is more reliable in the absence of a threshold effect the NRA and the Genotype® MTBDR assays should be primarily judged based on their areas under sROC, while the other tests can be reliably judged based on their pooled values.