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Table 1 Features in adults with and without hyperglycemia or severe hyperglycemia

From: Hyperglycemia in bacterial meningitis: a prospective cohort study

  Hyperglycemia glucose in mmol/L (mg/dL)   Severe hyperglycemia glucose in mmol/L (mg/dL)  
  <7.8 (140)
(n = 212)
≥ 7.8 (140)
(n = 470)
P <11.1 (200)
(n = 511)
≥ 11.1 (200)
(n = 171)
P
Age 44 (24–64) 55 (37–68) <0.001 48 (29–65) 59 (45–70) <0.0001
Seizures 2/206 (1%) 29/447 (7%) 0.001 20/493 (4%) 11/160 (7%) 0.2
Distant infection focus * 60/212 (28%) 175/470 (37%) 0.02 155/511 (30%) 80/171 (47%) <0.001
Diabetes 6/210 (3%) 40/466 (9%) 0.005 14/506 (3%) 32/170 (19%) <0.001
Immunocompromised 26/211 (12%) 83/470(18%) 0.09 62/510 (12%) 47/171 (28%) <0.001
GCS <14 127/211 (60%) 342/469 (73%) 0.001 327/510 (64%) 142/170 (84%) <0.001
GCS <8 (coma) 17/211 (8%) 77/469(16%) 0.004 58/510 (11%) 36/170 (21%) 0.002
DBP < 60 mmHg 32/201 (16%) 29/457 (6%) <0.001 58/490 (12%) 3/168 (2%) <0.001
HR > 120 bpm 27/212 (13%) 48/470 (10%) 0.3 53/511 (10%) 22/171 (13%) 0.4
T >38.0 154/200 (77%) 357/465(77%) 1.0 380/496 (77%) 131/169 (94%) 0.8
Focal neurologic deficits# 67/212 (32%) 161/470 (34%) 0.5 162/511 (32%) 66/171 (39%) 0.1
S. pneumoniae 88/212 (42%) 256/470 (55%) 0.007 228/511 (45%) 116/171 (68%) <0.001
CSF white cell count <1000 58/197 (29%) 76/436 (17%) 0.001 104/474 (22%) 30/159 (19%) 0.4
Platelet cell count 175 (121–237) 189 (147–240) 0.03 180 (139–236) 198 (150–253) 0.02
Positive blood culture 121/178(68%) 276/424 (65%) 0.5 295/447(66%) 102/155 (66%) 1.0
Unfavorable outcome 65/212 (31%) 163/470 (35%) 0.3 156/511 (31%) 72/171 (42%) 0.008
Mortality 38/212 (18%) 102/470 (22%) 0.3 96/513 (19%) 44/169 (26%) 0.05
  1. Numbers are number/number assessed (percentage) or median (interquartile range) unless otherwise indicated. GCS denotes Glasgow Coma Scale, DPB diastolic blood pressure, HR hear rate, T bodily temperature (grade Celsius), CSF cerebrospinal fluid. * Defined as otitis/sinusitis or pneumonia. #Defined as cranial nerve palsies, aphasia, monoparesis or hemiparesis