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Table 2 Effects of immunization with the SjGP-3 formulated by various adjuvants on induction of IgG and protective efficacy against challenge in mice

From: A Schistosoma japonicumchimeric protein with a novel adjuvant induced a polarized Th1 immune response and protection against liver egg burdens

Groups a IgG titers b Worm burdens
Mean ± SE
%Worm reduction Liver eggs (epg)
Mean ± SE c
% Egg reduction
Exp1 SjGP-3/CFA 1,890,000 19.8 ± 0.9 41.1* 20,900 ± 1,947 26.6*
  SjGP-3/ISA206 1,290,000 23.4 ± 1.4 30.4* 21,200 ± 2,307 25.6*
  SjGP-3/IMS1312 680,000 25.3 ± 1.2 24.7* 24,400 ± 2,604 14.4
  SjGP-3/ISA70M 1,790,000 27.8 ± 1.2 17.3* 15,100 ± 1,578 47.0*,#
  Control < 500 33.6 ± 1.0 / 28,500 ± 2,777 /
Exp2 SjGP-3/CFA 1,831,000 20.9 ± 1.2 38.2* 26,900 ± 2,557 29.6*
  SjGP-3/ISA206 1,160,000 24.0 ± 1.6 29.0* 28,300 ± 1,808 25.9*
  SjGP-3/IMS1312 783,000 24.7 ± 1.9 26.9* 31,500 ± 2,593 17.5
  SjGP-3/ISA70M 1,841,000 26.0 ± 0.9 23.1* 19,000 ± 1,817 50.3*,#
  Control < 500 33.8 ± 0.8 / 38,200 ± 3,428 /
  1. a: The number of mice per group is from 8 to 10; b:Cut-off value was determined based on the pre-immunized geometric mean and three standard deviations. c: Number of liver eggs was calculated as egg numbers per gram of liver (epg). *: p < 0.05 when compared with PBS control group. #: p < 0.05 when compared with other adjuvant groups. Each value was derived from the arithmetic means of individuals in the group.