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Table 1 Antibody titers, worm and egg burdens, protective efficacy in mice vaccinated with schistosome chimeric proteins

From: A Schistosoma japonicumchimeric protein with a novel adjuvant induced a polarized Th1 immune response and protection against liver egg burdens

Groupsa

IgG Titersb

Worm burden

%Worm reduction

Liver eggs (epg)

% Egg reduction

   

Mean ± SE

 

Mean ± SE c

 

SjGP-1

To SjGP-1

1,310,000

25.8 ± 1.3

27.7*

25,900 ± 2,124

27.7*

 

Pmy-F1

804,000

    
 

Sj26GST

112,000

    

SjGP-2

To SjGP-2

550,000

34.0 ± 1.6

4.2

32,100 ± 2,150

10.3

 

Pmy-F2

63,000

    
 

Sj26GST

19,000

    

SjGP-3

To SjGP-3

1,231,000

22.2 ± 1.6

37.5*,#

26,700 ± 2,011

25.4*

 

Pmy-F3

663,000

    
 

Sj26GST

142,000

    

SjGP-4

To SjGP-4

804,000

28.3 ± 1.9

20.7*

30,000 ± 3,291

16.2

 

Pmy-F4

136,000

    
 

Sj26GST

23,000

    

Sj26GST

To Sj26GST

230,000

30.8 ± 1.4

13.7

28,100 ± 1,524

21.5*

Control

To all above

500

35.7 ± 2.5

/

35,800 ± 3,178

/

  1. a: The number of mice per group is from 9 to 10; b: "Pmy-F1" to "Pmy-F4" represents the four paramyosin fragments, respectively. Cut-off value was determined based on the pre-immunized geometric mean and three standard deviations. c: Number of liver eggs was calculated as egg numbers per gram of liver (epg). *: p < 0.05 when compared with PBS control group. #: p < 0.05 when compared with Sj26GST group. Each value was derived from the arithmetic means of individuals in the group.