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Table 1 Antibody titers, worm and egg burdens, protective efficacy in mice vaccinated with schistosome chimeric proteins

From: A Schistosoma japonicumchimeric protein with a novel adjuvant induced a polarized Th1 immune response and protection against liver egg burdens

Groupsa IgG Titersb Worm burden %Worm reduction Liver eggs (epg) % Egg reduction
    Mean ± SE   Mean ± SE c  
SjGP-1 To SjGP-1 1,310,000 25.8 ± 1.3 27.7* 25,900 ± 2,124 27.7*
  Pmy-F1 804,000     
  Sj26GST 112,000     
SjGP-2 To SjGP-2 550,000 34.0 ± 1.6 4.2 32,100 ± 2,150 10.3
  Pmy-F2 63,000     
  Sj26GST 19,000     
SjGP-3 To SjGP-3 1,231,000 22.2 ± 1.6 37.5*,# 26,700 ± 2,011 25.4*
  Pmy-F3 663,000     
  Sj26GST 142,000     
SjGP-4 To SjGP-4 804,000 28.3 ± 1.9 20.7* 30,000 ± 3,291 16.2
  Pmy-F4 136,000     
  Sj26GST 23,000     
Sj26GST To Sj26GST 230,000 30.8 ± 1.4 13.7 28,100 ± 1,524 21.5*
Control To all above 500 35.7 ± 2.5 / 35,800 ± 3,178 /
  1. a: The number of mice per group is from 9 to 10; b: "Pmy-F1" to "Pmy-F4" represents the four paramyosin fragments, respectively. Cut-off value was determined based on the pre-immunized geometric mean and three standard deviations. c: Number of liver eggs was calculated as egg numbers per gram of liver (epg). *: p < 0.05 when compared with PBS control group. #: p < 0.05 when compared with Sj26GST group. Each value was derived from the arithmetic means of individuals in the group.