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Table 1 Mean bacterial concentration at time of treatment (0 hours ± SD, pooled data from all three groups), and after 4 or 8 hours of treatment respectively, expressed in log10 cfu/ml.

From: Daptomycin in experimental murine pneumococcal meningitis

Treatment 0 hours
(log10 cfu/ml)
4 hours
(Δlog10 cfu/ml)
8 hours
(Δlog10 cfu/ml)
Dexamethasone   -0.02 ± 1.49 1.31 ± 1.16
Dexamethasone/daptomycin* 6.24 ± 0.86 -1.33 ± 1.24 -2.33 ± 1.51
Dexamethasone/vancomycin#   -0.43 ± 1.49 -2.82 ± 1.36
  1. *Daptomycin 25 mg/kg intraperitoneally, administered at 0 hours.
  2. #Vancomycin 50 mg/kg intraperitoneally, administered at 0 and 4 hours.