Figure 6

Photomicrographs of brain from pre-treatment (16 hours) mice. Upper panels; H&E 400× left, caspase-3 400× right, and lower panels; H&E 400× left; cresyl echt violet 500× right. Meninges of the cerebellum showed a mild infiltrate of neutrophils (upper left panel), exhibiting multifocal positivity with the apoptosis marker (upper right panel). Foci of necrosis with hemorrhage in the brain stem (lower left panel), focally infiltrated by neutrophils and associated with bacterial cocci (lower right panel), were noted.