Skip to main content

Advertisement

Table 4 The clinical details and risk factors for neurological involvement of the nine fatal case children with HFMD seen in the study.

From: Identification and validation of clinical predictors for the risk of neurological involvement in children with hand, foot, and mouth disease in Sarawak

Patient Year
of the outbreak
Age (months) Day of illness at presentation Risk factors that were present at presentation Disease severity HEV71 detected? IVIG treatment Note
1 2000 11 Day 3 fever ≥ 3D, history of lethargy, temperature ≥ 38.5°C HFMD-CNS Yes No a.
2 2003 34 Day 5 fever ≥ 3D, history of lethargy HFMD-CNS Yes No b.
3 2003 32 Day 3 fever ≥ 3D, history of lethargy HFMD-CNS No No a.
4 2006 9 Day 1 history of lethargy, temperature ≥ 38.5°C HFMD-CNS Yes Yes c.
5 2006 8 Day 3 fever ≥ 3D, history of lethargy, temperature ≥ 38.5°C HFMD-CNS Yes No a.
6 2006 14 Day 3 fever ≥ 3D, history of lethargy, temperature ≥ 38.5°C HFMD-CNS Yes No a.
7 2006 34 Day 4 fever ≥ 3D, history of lethargy, temperature ≥ 38.5°C HFMD-CNS Yes No a.
8 2006 25 Day 4 fever ≥ 3D, history of lethargy, temperature ≥ 38.5°C HFMD-CNS No No a.
9 2006 47 Day 4 fever ≥ 3D, history of lethargy HFMD-CNS No No a.
  1. Note:
  2. a. Presented in the moribund state with fulminant cardiorespiratory failure and pulmonary oedema. The patient died within 24 hours of the hospitalization. The risk factors were present for ≥ 48 hours before hospital admission.
  3. b. Developed acute cardiorespiratory collapse and died 12 hours after hospitalization. Had peak temperature ≥ 38.5°C in the hospital. The patient was lethargic for ≥ 48 hours before hospital admission.
  4. c. Deteriorated progressively because of cardiorespiratory failure despite intensive care support. Died on day 4 of the hospitalization. The patient was lethargic for 24 hours before hospital admission
  5. HFMD-CNS: Hand, foot and mouth disease with central nervous system complication
  6. IVIG: Intravenous immunoglobulin