Skip to main content

Table 2 Characteristics of Included Trials

From: Antimicrobial drugs for persistent diarrhoea of unknown or non-specific cause in children under six in low and middle income countries: systematic review of randomized controlled trials

Location and date of publication Participants Setting Interventions Outcomes Source of Support
1992 [18]
Number: 102
Girls and boys, 3–35 mths
Diarrhoea 14–18 days, weight for length not
< -2 Z, no dysentery
Surveillance project: rural indigenous community
Field nurse visited homes three times daily to deliver intervention
Group 1: 10 mg oral gentamicin sulphate per kg body weight per day: 3× daily for 5 days.
Group 2: Placebo: 1% magnesium sulphate 3× daily for 5 days.
Diarrhoea stopped at 7 days, and at least 48 hrs after end of treatment None stated
India 1992 [15] Number: 68
Boys, 3 mths to 4 yrs
Diarrhoea ≥ 14 days, weight for length ≤ 90% of standard, no dysentery
Hospital oral rehydration unit in New Delhi
Field worker visited homes twice daily to deliver intervention and leave evening dose
Group 1: 50 mg oral gentamicin per kg body weight per day: 4 times daily for 6 days
Group 2: Placebo
≤ 2 liquid stools per day at 6 days.
Intake of IV fluids, ORS, water and energy.
Output of diarrhoea, vomit and urine.
Weight change at 168 hrs
Diarrhoeal Diseases Control Programme, World Health Organization
India 1996 [16] Number: 156
Girls and boys, 4 mths to 3 yrs
Diarrhoea ≥ 14 days <4 weeks, no dysentery, Giardia lamblia or Entamoeba histolytica, no illness requiring antibiotics
Surveillance project with referrals to clinic and direct clinic attendances: urban slum in Delhi
Group 1: 30 mg oral metronidazole plus 50 mg oral nalidixic acid per kg body weight: 3× daily for 7 days
Group 2: 30 mg oral metronidazole per kg body weight: 3× daily for 7 days
Group 3: Placebo
First of 3 days with < 3 liquid stools in a 24 hrs; days 3, 5 and 7.
No. stools in previous 24 hrs; days 2, 5 and 7.
Weight change at days 7 and 14
CDR, World Health Organization
Bangladesh 1995 [17] Number: 55
Girls and boys, 6 to 15 mths
Diarrhoea ≥ 14 days <6 weeks No systemic infection, antibacterial use previous 7 days, severe malnutrition, Vibrio cholerae, Salmonella, Shigella, Giardia lamblia or Entamoeba histolytica
Clinical research unit of specialist diarrhoea hospital
Group 1: 10 mg oral trimethoprim plus 50 mg sulphamethoxazole per kg body weight; 2× daily for 7 days
Group 2: Placebo,
Diarrhoea stopped at 7 days.
Stool output (g/kg) days 1,2,3,4,5,6 and 7, plus all days 1–7 combined.
Duration of diarrhoea.
Hospital infection.
Energy intake (kcal/kg/day)
United States Agency for International Development and the International Centre for Diarrhoeal Disease Research, Bangladesh