Table 5 Sensitivity analysis (in US$) based on screening of 1000 suspects, comparing AFB smear plus Culture, and AFB smear plus PCR dot-blot
From: Cost-effectiveness analysis of PCR for the rapid diagnosis of pulmonary tuberculosis
Cost per accurately diagnosed case of TB | Cost per case accurately diagnosed and treated, including treatment of falsely diagnosed cases | Cost per case incorrectly diagnosed and not treated** | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Component | Current situation | Adjustment | AFB smear plus Culture | AFB smear plus PCR dot-blot | Ratio | AFB smear plus Culture | AFB smear plus PCR dot-blot | Ratio | AFB smear plus Culture | AFB smear plus PCR dot-blot | Ratio |
TB prevalence | 46% | No adjustment | 50,773 | 13,749 | 3.7 | 55,501 | 15,190 | 3.6 | 22,045,767, | 5,836,887 | 3.8 |
10% | 233,554 | 63,246 | 3.7 | 255,304 | 69,874 | 3.6 | 124,926,015 | 27,725,214 | 4.5 | ||
20% | 116,777 | 31,623 | 3.7 | 127,652 | 34,937 | 3.6 | 20,821,002 $ | 3,960,745 | 5.3 | ||
40% | 58,389 | 15,812 | 3.7 | 63,826 | 17,469 | 3.6 | 9,609,693 | 1,980,372 | 4.9 | ||
60% | 38,926 | 10,541 | 3.7 | 42,551 | 11,646 | 3.6 | 505,773 | 94,303 | 5.4 | ||
Sensitivity PCR dot-blot | 85% | 95% | 46,577 | 12,386 | 3.7 | 50,914 | 13,683 | 3.7 | 3,097,339 | 916,536 | 3.4 |
Specificity PCR dot-blot | 85% | 95% | 39,688 | 10,554 | 3.7 | 43,384 | 11,659 | 3.7 | 2,639,282 | 780,992 | 3.4 |
PCR dot-blot running costs* | 12,833 | 10,000 | 50,772 | 13,723 | 3.7 | 55,501 | 15,164 | 3.7 | 20,045,767 | 5,825,852 | 3.8 |