Table 4 Costs (in US$) and Cost-effectiveness (in US$) of screening 1000 TB suspects, comparing AFB smear plus Culture and AFB smear plus PCR dot-blot.
From: Cost-effectiveness analysis of PCR for the rapid diagnosis of pulmonary tuberculosis
AFB smear plus Culture | AFB smear plus PCR dot-blot | |
|---|---|---|
Total number of accurately diagnosed cases of TB | 111 | 109 |
Total number correctly diagnosed cases of non TB | 148 | 127 |
False positives | 1 | 22 |
False negatives | 17 | 19 |
Estimate of false negatives in 1000 TB suspects | 133 (13.3%) | 148 (14.8%) |
Estimate of cases of TB (5%) using the estimative of transmission of false negatives in 1000 TB suspects | 66,5 | 74 |
4. A Total Costs | (US$) | (US$) |
Total Health Service Costs | 5,444,960 | 1,464,660 |
Total Patient Costs | 190,800 | 34,000 |
Total Screening Costs | 5,635,760 | 1,498,660 |
Total Screening Costs per patient | 5,635 | 1,498 |
4. B Cost-effectiveness of screening of 1000 suspects | ||
Cost per accurately diagnosed case of TB | 50,773 | 13,749 |
Cost per accurately diagnosed case of TB, considering only health service costs | 49,053 | 13,437 |
Cost per accurately diagnosed case of TB, considering only patient cost | 1,720 | 312 |
Cost of treating all correctly diagnosed TB cases (true positives cases) (ambulatory/outpatients) | 176,338 | 92,523 |
Cost of treating all correctly diagnosed TB cases (true positives cases) (hospital/inpatients) | 298,187 | 53,087 |
Cost of treating all falsely diagnosed TB cases (false positives cases) (ambulatory/outpatients) | 1,589 | 18,674 |
Cost of treating all falsely diagnosed TB cases (false positives cases) (hospital/inpatients) | 2,686 | 10,715 |
Cost per case of TB correctly diagnosed and case of TB falsely diagnosed and treated (true positives and false positives) a | 50,319 | 11,440 |
Cost of treatment of false negatives cases of TB (Treatment costs vs false negative cases) | 72,675 | 25,382 |
Cost per case of non-TB correctly and incorrectly diagnosed and not treated (true negatives and false negatives) | 34,156 | 10,260 |
Cost of return of all false negatives to the health service (Estimate of cases of TB (5%) using the estimative of transmission of false negatives in 1000 TB suspects vs Total Screening Costs b | 374,778,045 | 110,900,055 |