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Table 3 Distribution of T cell subsets in peripheral blood from HIV/HTLV-1 co-infected, HIV mono-infected and healthy Mozambican subjects

From: Co-infection by human immunodeficiency virus type 1 (HIV-1) and human T cell leukemia virus type 1 (HTLV-1): does immune activation lead to a faster progression to AIDS?

T cell subsets and viral load

HIV/HTLV-1

(n = 29)

HIV

(n = 59)

HC

(n = 16)

CD4+ T cell counts (cells/mm3)

   

   Median

525a

274

472

   IQR

310 - 827

183 - 436

412 - 775

CD4 + T cell counts (%)

   

   Median

24.9 a, b

15.9

45.0

   IQR

19.0 - 32.7

9.4 - 21.0

37.0 - 48.0

CD8 + T cell counts, cells/mm 3

   

   Median

1002b

937

302

   IQR

649 - 1090

606 - 1358

190 - 391

CD8 + T cell counts, %

   

   Median

46.8a, b

54.2

23.0

   IQR

36.2 - 53.0

42.7 - 61.3

21.0 - 29.0

CD4 + T/CD8 + T ratio

   

   Median

0.5a, b

0.3

1.8

   IQR

0.3 - 0.8

0.2 - 0.4

1.2 - 2.5

CD8 + CD38 + T cells (MFI)

   

   Median

341.5

279.9

209.7

   IQR

285.1 - 367.1

225.4 - 373.3

209.7 - 225.4

HIV-1 RNA viral load (copies/mL)

   

   Median

56,385

37,573

 

   IQR

14,749 - 277,570

11,322-176,837

 
  1. One ANOVA corrected by Bonferoni was used to compare groups.
  2. HIV/HTLV-1, HIV/HTLV-1 co-infected; HIV, HIV mono-infected; HC, healthy controls; MFI, Median Fluorescence Intensity
  3. a p < 0.05 comparison co-infected versus HIV mono-infected
  4. b p < 0.05 comparison co-infected versus healthy controls