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Table 5 Odds of active TB according to lymphocyte proliferation assays, stratified by CD4 count and HIV viral load.

From: Lymphocyte proliferation to mycobacterial antigens is detectable across a spectrum of HIV-associated tuberculosis

Odds of TB if PI ≥ 5 to Antigen

 

By CD4 count strata

By HIV Viral Load Quartile

Antigen

CD4 count ≥ 350*

CD4 count < 350

P value by Mantel-Haenszel method

Lowest

Second

Third

Highest

P value by Mantel-Haenszel method

ESAT-6

15.8

2.9

0.0003

0

0

12.2

6.8

0.0030

Ag85

15.2

5.9

< 0.0001

0

0

11.2

7.1

0.0022

WCL

3.3

4.8

0.0098

0

0

0

2.7

0.0333

  1. * Of subjects with active TB, six had CD4 counts ≥ 350
  2. Ag85, antigen 85; ESAT-6, early secretory antigenic target 6; PI, proliferative index; TB, tuberculosis; WCL, Mycobacterium tuberculosis whole cell lysate
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BMC Infectious Diseases

ISSN: 1471-2334

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