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Table 3 Prevalence of detectable lymphocyte proliferation to mycobacterial antigens in HIV-infected BCG-vaccinated adults with and without active TB.

From: Lymphocyte proliferation to mycobacterial antigens is detectable across a spectrum of HIV-associated tuberculosis

Antigen

Subjects without TB

(n = 13)

Subjects with latent TB

(n = 635)

Subjects with active TB

n = 1206)

P-value by ANOVA

PHA, % (n)

543 (45.0%)

278 (43.8%)

8 (61.5%)

0.4175

MVS, % (n)

26 (2.2%)

21 (3.3%)

0 (0%)

0.2756

ESAT-6, % (n)

66 (5.5%)

84 (13.2%)

5 (38.5%)

< 0.0001

Ag85, % (n)

38 (3.1%)

119 (18.7%)

6 (46.2%)

< 0.0001

WCL, % (n)

207 (17.1%)

290 (45.7%)

8 (61.5%)

< 0.0001

  1. Ag85, antigen 85; ESAT-6, early secretory antigenic target 6; MVS, Mycobacterium vaccae sonicate; PHA, phytohemagglutinin; TB, tuberculosis; WCL, Mycobacterium tuberculosis whole cell lysate