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Table 1 Comparison of the clinical and laboratory characteristics of the normal adrenal response group and the adrenal insufficiency group of patients

From: Serum macrophage migration inhibitory factor reflects adrenal function in the hypothalamo-pituitary-adrenal axis of septic patients: an observational study

 

NAR group (n = 22)

AI group (n = 19)

Pvalue

Age (yrs)

67 (50-71)

68 (55-74)

0.574

Male (n)

14

16

0.233

APACHE II

27 (21-29)

27 (19-32)

0.582

SOFA score

9 (5-11)

8 (6-11)

0.793

JAAM DIC score

3.0 (1.75-5.0)

3.0 (2.0-5.0)

0.433

Severe sepsis/septic shock (n)

19/3

7/12

0.001

Survivors/non-survivors (n)

16/6

13/6

0.763

Albumin (g/dL)

2.1 (1.7-2.5)

2.0 (1.6-2.2)

0.636

Prothrombin time ratio

1.2 (1.1-1.3)

1.3 (1.2-1.5)

0.025

MIF (ng/mL)

16.6 (14.5-20.1)

23.8 (17.6-44.5)

0.010

Baseline cortisol (μg/dL)

18.9 (14.3-25.3)

27.6 (17.6-46.8)

0.028

Baseline cortisol/albumin ratio

10.3 (8.6-13.0)

15.1 (9.4-20.0)

0.053

Delta max cortisol (μg/dL)

15.5 (9.9-19.6)

4.6 (1.4-7.3)

< 0.001

Delta max cortisol/albumin ratio

7.5 (6.0-8.5)

2.3 (0.8-3.3)

< 0.001

Site of infection (n)

   

Respiratory tract

11

7

 

Skin and soft tissue

3

5

 

Gastrointestinal tract

2

3

 

Urinary tract

1

2

 

Peritonitis

2

1

 

Meningitis

1

0

 

Infectious endocarditis

1

0

 

Unknown

0

1

 
  1. All values are presented as medians (interquartile ranges).
  2. NAR: normal adrenal response; AI: adrenal insufficiency; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA score: Sequential Organ Failure Assessment score; JAAM DIC score: Disseminated Intravascular Coagulation score established by the Japanese Association for Acute Medicine; Prothrombin time ratio: the ratio of the actual prothrombin time vs the normal control prothrombin time; MIF: macrophage migration inhibitory factor; Delta max cortisol: maximum increment in the cortisol concentration caused by the adrenocorticotropic hormone stimulation test.