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Table 1 Comparison of the clinical and laboratory characteristics of the normal adrenal response group and the adrenal insufficiency group of patients

From: Serum macrophage migration inhibitory factor reflects adrenal function in the hypothalamo-pituitary-adrenal axis of septic patients: an observational study

  NAR group (n = 22) AI group (n = 19) Pvalue
Age (yrs) 67 (50-71) 68 (55-74) 0.574
Male (n) 14 16 0.233
APACHE II 27 (21-29) 27 (19-32) 0.582
SOFA score 9 (5-11) 8 (6-11) 0.793
JAAM DIC score 3.0 (1.75-5.0) 3.0 (2.0-5.0) 0.433
Severe sepsis/septic shock (n) 19/3 7/12 0.001
Survivors/non-survivors (n) 16/6 13/6 0.763
Albumin (g/dL) 2.1 (1.7-2.5) 2.0 (1.6-2.2) 0.636
Prothrombin time ratio 1.2 (1.1-1.3) 1.3 (1.2-1.5) 0.025
MIF (ng/mL) 16.6 (14.5-20.1) 23.8 (17.6-44.5) 0.010
Baseline cortisol (μg/dL) 18.9 (14.3-25.3) 27.6 (17.6-46.8) 0.028
Baseline cortisol/albumin ratio 10.3 (8.6-13.0) 15.1 (9.4-20.0) 0.053
Delta max cortisol (μg/dL) 15.5 (9.9-19.6) 4.6 (1.4-7.3) < 0.001
Delta max cortisol/albumin ratio 7.5 (6.0-8.5) 2.3 (0.8-3.3) < 0.001
Site of infection (n)    
Respiratory tract 11 7  
Skin and soft tissue 3 5  
Gastrointestinal tract 2 3  
Urinary tract 1 2  
Peritonitis 2 1  
Meningitis 1 0  
Infectious endocarditis 1 0  
Unknown 0 1  
  1. All values are presented as medians (interquartile ranges).
  2. NAR: normal adrenal response; AI: adrenal insufficiency; APACHE II: Acute Physiology and Chronic Health Evaluation II; SOFA score: Sequential Organ Failure Assessment score; JAAM DIC score: Disseminated Intravascular Coagulation score established by the Japanese Association for Acute Medicine; Prothrombin time ratio: the ratio of the actual prothrombin time vs the normal control prothrombin time; MIF: macrophage migration inhibitory factor; Delta max cortisol: maximum increment in the cortisol concentration caused by the adrenocorticotropic hormone stimulation test.