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Table 4 Comparison of HLA haplotypes and genotypes in HIV-1 positive and population control groups

From: Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in Chongqing, China

Haplotype/Genotype No. of
HIV-1 Positive
N (%)
No. of
Population Control
N (%)
P value Corrected P value Odds ratios 95%CI
2-locus Haplotype       
A*11 B*46 50 (9.1) 143 (5.8) 0.005 0.012 1.630 1.15-2.32
A*24 B*54 26 (4.7) 57 (2.3) 0.003 0.012 2.110 1.28-3.46
A*01 B*37 16 (2.9) 34 (1.4) 0.017 0.017 2.160 1.13-4.07
A*11 B*1502G 30 (5.5) 220 (8.9) 0.011 0.012 0.590 0.39-0.89
3-locus Haplotype       
A*11 B*46 DRB1*09 35 (6.4) 92 (3.7) 0.007 0.032 1.760 1.16-2.68
A*02 B*46 DRB1*08 30 (5.5) 82 (3.3) 0.022 0.038 1.690 1.07-2.64
A*11 B*4001G DRB1*15 21 (3.8) 29 (1.2) <0.0001 0.0007 3.350 1.83-6.13
A*02 B*4001G DRB1*04 11 (2.0) 17 (0.7) 0.008 0.032 2.960 1.29-6.70
A*11 B*46 DRB1*08 11 (2.0) 9 (0.4) <0.0001 0.0007 5.600 2.15-14.74
A*02 B*4001G DRB1*12 9 (1.6) 16 (0.6) 0.039 0.039 2.560 1.04-6.17
A*11 B*1502G DRB1*12 7 (1.3) 126 (5.1) 0.0001 0.0007 0.240 0.10-0.54
A*33 B*58 DRB1*13 9 (1.6) 86 (3.5) 0.036 0.039 0.460 0.22-0.96
Homozygosity       
A-A 120 (21.9) 590 (23.8) 0.96 0.96 1.00 0.73-1.35
B-B 43 (7.8) 198 (8.0) 0.23 0.35 0.89 0.73-1.08
DRB1-DRB1 61 (11.1) 265 (10.7) 0.23 0.35 1.13 0.93-1.36
Serological group       
Bw4-Bw4 61 (11.1) 276 (11.1) 0.35 0.96 0.89 0.71-1.12
Bw6-Bw6 226 (41.2) 1091 (44.1) 0.96 0.96 0.98 0.68-1.40
Bw4-Bw6 262 (47.7) 1108 (44.8) 0.84 0.96 1.04 0.77-1.41
  1. "N" indicates the number of people with a given haplotype/genotype. The percentage is indicated in parentheses; P value with Yates' correction; CI, confidence interval.
  2. : indicates P value and corrected P value (adjusted with False discovery rate for multiple testing) <0.05 of comparative distribution of haplotypes and genotypes in the HIV-1 positive and population control group.