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Table 2 Cytokine profiles from patient peripheral blood mononuclear cell supernatants before and four months following methotrexate (MTX) treatment.

From: Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies

  pg/ml
   Patient cells††
Cytokine Healthy controls Before MTX After MTX
IFN-γ 0-10 13 <10
IL-1β 0-10 1 100 2
IL-6 0-35 9 482 864
IL-8 150-2000 1 4795 1094
IL-10 0-10 425 4
TNF-α 0-60 92 <10
  1. Cytokine levels in supernatants from cells incubated 48 h in medium alone and quantified using FlowCytomix Human Th1/Th2 Kit as recommended (Bender Medsystems, Vienna, Austria, http://www.bendermedsystems.com).
  2. †† No cytokine was detected in serum. IFN-α, IL-2, IL-4, IL-5 and IL-12 were not detected in these samples.