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Table 2 Cytokine profiles from patient peripheral blood mononuclear cell supernatants before and four months following methotrexate (MTX) treatment.

From: Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies

 

pg/ml†

  

Patient cells††

Cytokine

Healthy controls

Before MTX

After MTX

IFN-γ

0-10

13

<10

IL-1β

0-10

1 100

2

IL-6

0-35

9 482

864

IL-8

150-2000

1 4795

1094

IL-10

0-10

425

4

TNF-α

0-60

92

<10

  1. † Cytokine levels in supernatants from cells incubated 48 h in medium alone and quantified using FlowCytomix Human Th1/Th2 Kit as recommended (Bender Medsystems, Vienna, Austria, http://www.bendermedsystems.com).
  2. †† No cytokine was detected in serum. IFN-α, IL-2, IL-4, IL-5 and IL-12 were not detected in these samples.
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BMC Infectious Diseases

ISSN: 1471-2334

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