Table 1 Gene expression profile in a patient with chikungunya virus infection before and four months following methotrexate (MTX) treatment.
Gene Name | Unigene ID | Description | Before MTX Fold/Control | After MTX Fold/Control | Before/after Fold †† |
|---|---|---|---|---|---|
Inflammatory mediators | |||||
TNF-α | 241570 | Tumor necrosis factor-α (TNFsuperfamily, member 2) | 9† | -15 | -135 |
LTA | 36 | Lymphotoxin alpha (TNF superfamily, member 1) | 1 | -10 | -13 |
CRP | 76452 | C-reactive protein, pentraxin-related | 12 | -3 | -33 |
IL-1A | 1722 | Interleukin 1, alpha | 2 | -5 | -9 |
IL-1F5 | 516301 | Interleukin 1 family, member 5 (delta) | 84 | 1 | -90 |
IL-1F6 | 278910 | Interleukin 1 family, member 6 (epsilon) | 2 | -9 | -20 |
IL-1F7 | 166371 | Interleukin 1 family, member 7 (zeta) | 4 | -3 | -11 |
IL-1F8 | 278909 | Interleukin 1 family, member 8 (eta) | 7 | -4 | -28 |
IL-1F9 | 211238 | Interleukin 1 family, member 9 | 8 | -2 | -20 |
IL-1RN | 81134 | Interleukin 1 receptor antagonist | 49 | -3 | -167 |
IL-9 | 960 | Interleukin 9 | 3 | -6 | -20 |
IL-9R | 406228 | Interleukin 9 receptor | 5 | -3 | -15 |
IL-17C | 278911 | Interleukin 17C | 10 | 1 | -10 |
SPP1 | 313 | Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 7 | -2 | -15 |
C3 | 529053 | Complement component 3 | 12.25 | 19 | 1 |
Th2-related factors | |||||
IL-13 | 845 | Interleukin 13 | 5 | -11 | -55 |
IL-22 | 287369 | Interleukin 22 | OFF | OFF | -- |
CD40L | 592244 | CD40 ligand (TNF superfamily, hyper-IgM syndrome) | OFF | OFF | -- |
Inflammatory chemokines and their receptors | |||||
IFN-α | 211575 | Interferon-α2 | OFF | OFF | -- |
IL-8 | 624 | Interleukin 8 | 5 | 1 | -5 |
XCR1 | 248116 | Chemokine (C motif) receptor 1 | 34 | -2 | -62 |
CCL1 | 72918 | Chemokine (C-C motif) ligand 1 | 4 | -31 | -109 |
CCL7 | 251526 | Chemokine (C-C motif) ligand 7 | 3 | -14 | -40 |
CCL8 | 271387 | Chemokine (C-C motif) ligand 8 | 2 | -46 | -80 |
CCL16 | 10458 | Chemokine (C-C motif) ligand 16 | 6 | -3 | -22 |
CCL24 | 247838 | Chemokine (C-C motif) ligand 24 | 76 | -3 | -190 |
CCL26 | 131342 | Chemokine (C-C motif) ligand 26 | 7 | -2 | -15 |
CCR2 | 644637 | Chemokine (C-C motif) receptor 2 | 13 | 89 | 7 |
CCR6 | 46468 | Chemokine (C-C motif) receptor 6 | 4 | -5 | -17 |
CCR8 | 113222 | Chemokine (C-C motif) receptor 8 | 8 | -2 | -19 |
CCR9 | 225946 | Chemokine (C-C motif) receptor 9 | 5 | -3 | -15 |
CXCL2 | 590921 | Chemokine (C-X-C motif) ligand 2 | OFF | 2 | ON |
CXCL5 | 89714 | Chemokine (C-X-C motif) ligand 5 | 27 | 4 | -7 |
CXCL14 | 483444 | Chemokine (C-X-C motif) ligand 14 | OFF | 1 | ON |