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Table 1 Gene expression profile in a patient with chikungunya virus infection before and four months following methotrexate (MTX) treatment.

From: Destructive arthritis in a patient with chikungunya virus infection with persistent specific IgM antibodies

Gene Name Unigene ID Description Before MTX Fold/Control After MTX Fold/Control Before/after Fold ††
Inflammatory mediators
TNF-α 241570 Tumor necrosis factor-α (TNFsuperfamily, member 2) 9† -15 -135
LTA 36 Lymphotoxin alpha (TNF superfamily, member 1) 1 -10 -13
CRP 76452 C-reactive protein, pentraxin-related 12 -3 -33
IL-1A 1722 Interleukin 1, alpha 2 -5 -9
IL-1F5 516301 Interleukin 1 family, member 5 (delta) 84 1 -90
IL-1F6 278910 Interleukin 1 family, member 6 (epsilon) 2 -9 -20
IL-1F7 166371 Interleukin 1 family, member 7 (zeta) 4 -3 -11
IL-1F8 278909 Interleukin 1 family, member 8 (eta) 7 -4 -28
IL-1F9 211238 Interleukin 1 family, member 9 8 -2 -20
IL-1RN 81134 Interleukin 1 receptor antagonist 49 -3 -167
IL-9 960 Interleukin 9 3 -6 -20
IL-9R 406228 Interleukin 9 receptor 5 -3 -15
IL-17C 278911 Interleukin 17C 10 1 -10
SPP1 313 Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) 7 -2 -15
C3 529053 Complement component 3 12.25 19 1
Th2-related factors
IL-13 845 Interleukin 13 5 -11 -55
IL-22 287369 Interleukin 22 OFF OFF --
CD40L 592244 CD40 ligand (TNF superfamily, hyper-IgM syndrome) OFF OFF --
Inflammatory chemokines and their receptors
IFN-α 211575 Interferon-α2 OFF OFF --
IL-8 624 Interleukin 8 5 1 -5
XCR1 248116 Chemokine (C motif) receptor 1 34 -2 -62
CCL1 72918 Chemokine (C-C motif) ligand 1 4 -31 -109
CCL7 251526 Chemokine (C-C motif) ligand 7 3 -14 -40
CCL8 271387 Chemokine (C-C motif) ligand 8 2 -46 -80
CCL16 10458 Chemokine (C-C motif) ligand 16 6 -3 -22
CCL24 247838 Chemokine (C-C motif) ligand 24 76 -3 -190
CCL26 131342 Chemokine (C-C motif) ligand 26 7 -2 -15
CCR2 644637 Chemokine (C-C motif) receptor 2 13 89 7
CCR6 46468 Chemokine (C-C motif) receptor 6 4 -5 -17
CCR8 113222 Chemokine (C-C motif) receptor 8 8 -2 -19
CCR9 225946 Chemokine (C-C motif) receptor 9 5 -3 -15
CXCL2 590921 Chemokine (C-X-C motif) ligand 2 OFF 2 ON
CXCL5 89714 Chemokine (C-X-C motif) ligand 5 27 4 -7
CXCL14 483444 Chemokine (C-X-C motif) ligand 14 OFF 1 ON
  1. Patient had persistent specific IgM antibodies and erosive arthritis for two years before treatment.
  2. † gene expression in patient peripheral blood mononuclear cells compared to those observed in cells from three healthy controls using real-time RT-PCR. Results shown as fold expression compared to control values. Inflammatory arrays were performed using RT2 Profiler PCR Array System (Ref: APHS-011B, SuperArray, Frederick, USA, http://www.superarray.com
  3. †† Comparison of gene expression before MTX treatment and following 4 months therapy