Table 2 Clinical and parasitological responses

Number of children

30

30

26

26

Primary endpoints

Proportion achieving well clinical response (number, %)

14 (47)

12 (40)

11 (42)

8 (31)

Time to well clinical response(days)

11.4 (7.2)

7.9 (4.8)

12.2 (9.6)

13.8 (9.7)

Secondary endpoints

Parasitological eradication (number, %)

10 (33)

12 (40)

7 (27)

9 (35)

Time to parasite eradication (days)

8.7 (7.0)

11.7 (9.0)

8.0 (6.3)

13.8 (9.5)

Time to combined clinical and parasitological response

19.1 (11.5)

20.3 (10.1)

12.7 (8.4)

14.2 (7.8)

Mortality (deaths by 4 weeks)

11 (37)

6 (20)

10 (38)

6 (23)

Rate of reduction in stool frequency (expressed as change per day during treatment) (mean, SD)

-0.21 (0.34)

-0.16 (0.25)

-

-

Nutritional response (change in weight over 4 weeks, kg) (mean, SD)

0.8 (1.0)

1.2 (0.9)

1.3 (0.8)

1.6 (0.8)