S/N

1^{st} Assay

2^{nd} Assay

Sensitivity % (95% CI)

Specificity % (95% CI)

Cost per algorithm (US$)


1

SD Bioline

First Response

100 (99.1–100)

99.9** (99.5–99.9)

0.47 + 0.65 = 1.12

2

First Response***

SD Bioline

99.5 (98.2–99.9)

100 (96–99.1)

0.65 + 0.47 = 1.12

3

SD Bioline

Determine

100 (99.1–100)

100* (96–99.1)

0.47 + 0.80 = 1.27

4

Determine

SD Bioline

100 (99.1–100)

100* (96–99.1)

0.80 + 0.47 = 1.27

5

SD Bioline

StatPak Dipstick

100 (99.1–100)

100* (96–99.1)

0.47 + 0.80 = 1.27

6

StatPak Dipstick***

SD Bioline

97.9 (96–99.1)

100 (96–99.1)

0.80 + 0.47 = 1.27

7

Determine

First Response

100 (99.1–100)

100* (96–99.1)

0.80 + 0.65 = 1.45

8

First Response***

Determine

99.5 (98.2–99.9)

99.9 (99.5–99.9)

0.65 + 0.80 = 1.45

9

First Response***

StatPak Dipstick

99.5 (98.2–99.9)

100 (96–99.1)

0.65 + 0.80 = 1.45

10

StatPak Dipstick***

First Response

97.9 (96–99.1)

100 (96–99.1)

0.80 + 0.65 = 1.45

11

Determine

StatPak Dipstick

100 (99.1–100)

100* (96–99.1)

0.80 + 0.80 = 1.60

12

StatPak Dipstick***

Determine

97.9 (96–99.1)

100 (96–99.1)

0.80 + 0.80 = 1.60

13

SD Bioline

UniGold™

100 (99.1–100)

100* (96–99.1)

0.47 + 1.80 = 2.27

14

UniGold™

SD Bioline

100 (99.1–100)

100* (96–99.1)

1.80 + 0.47 = 2.27

15

UniGold™

First Response

100 (99.1–100)

100* (96–99.1)

1.80 + 0.65 = 2.45

16

First Response***

UniGold™

99.5 (98.2–99.9)

100 (96–99.1)

0.65 + 1.80 = 2.45

17

UniGold™

StatPak Dipstick

100 (99.1–100)

100* (96–99.1)

1.80 + 0.80**** = 2.6

18

StatPak Dipstick***

UniGold™

97.9 (96–99.1)

100 (96–99.1)

0.80 + 1.80 = 2.60

19

Determine

UniGold™

100 (99.1–100)

100* (96–99.1)

0.80 + 1.80 = 2.60

20

UniGold™

Determine

100 (99.1–100)

100* (96–99.1)

1.80 + 0.80 = 2.60

 *Combination of the two assays had no concordant false positive results.
 **One sample was repeatedly concordantly false positive in the two assays.
 ***The first test had initial suboptimal sensitivity (< 100%).
 ****Cost of StatPak Dipstick is indicated as a range 0.8–0.95 US$. The best case scenario of the lowest possible cost for this test was assumed in computing the cost for algorithms involving use of StatPak Dipstick.