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Table 3 Sensitivity (n = 390), specificity (n = 1043) and cost of various combinations of rapid HIV assays

From: Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania

S/N

1st Assay

2nd Assay

Sensitivity % (95% CI)

Specificity % (95% CI)

Cost per algorithm (US$)

1

SD Bioline

First Response

100 (99.1–100)

99.9** (99.5–99.9)

0.47 + 0.65 = 1.12

2

First Response***

SD Bioline

99.5 (98.2–99.9)

100 (96–99.1)

0.65 + 0.47 = 1.12

3

SD Bioline

Determine

100 (99.1–100)

100* (96–99.1)

0.47 + 0.80 = 1.27

4

Determine

SD Bioline

100 (99.1–100)

100* (96–99.1)

0.80 + 0.47 = 1.27

5

SD Bioline

Stat-Pak Dipstick

100 (99.1–100)

100* (96–99.1)

0.47 + 0.80 = 1.27

6

Stat-Pak Dipstick***

SD Bioline

97.9 (96–99.1)

100 (96–99.1)

0.80 + 0.47 = 1.27

7

Determine

First Response

100 (99.1–100)

100* (96–99.1)

0.80 + 0.65 = 1.45

8

First Response***

Determine

99.5 (98.2–99.9)

99.9 (99.5–99.9)

0.65 + 0.80 = 1.45

9

First Response***

Stat-Pak Dipstick

99.5 (98.2–99.9)

100 (96–99.1)

0.65 + 0.80 = 1.45

10

Stat-Pak Dipstick***

First Response

97.9 (96–99.1)

100 (96–99.1)

0.80 + 0.65 = 1.45

11

Determine

Stat-Pak Dipstick

100 (99.1–100)

100* (96–99.1)

0.80 + 0.80 = 1.60

12

Stat-Pak Dipstick***

Determine

97.9 (96–99.1)

100 (96–99.1)

0.80 + 0.80 = 1.60

13

SD Bioline

Uni-Gold™

100 (99.1–100)

100* (96–99.1)

0.47 + 1.80 = 2.27

14

Uni-Gold™

SD Bioline

100 (99.1–100)

100* (96–99.1)

1.80 + 0.47 = 2.27

15

Uni-Gold™

First Response

100 (99.1–100)

100* (96–99.1)

1.80 + 0.65 = 2.45

16

First Response***

Uni-Gold™

99.5 (98.2–99.9)

100 (96–99.1)

0.65 + 1.80 = 2.45

17

Uni-Gold™

Stat-Pak Dipstick

100 (99.1–100)

100* (96–99.1)

1.80 + 0.80**** = 2.6

18

Stat-Pak Dipstick***

Uni-Gold™

97.9 (96–99.1)

100 (96–99.1)

0.80 + 1.80 = 2.60

19

Determine

Uni-Gold™

100 (99.1–100)

100* (96–99.1)

0.80 + 1.80 = 2.60

20

Uni-Gold™

Determine

100 (99.1–100)

100* (96–99.1)

1.80 + 0.80 = 2.60

  1. *Combination of the two assays had no concordant false positive results.
  2. **One sample was repeatedly concordantly false positive in the two assays.
  3. ***The first test had initial suboptimal sensitivity (< 100%).
  4. ****Cost of Stat-Pak Dipstick is indicated as a range 0.8–0.95 US$. The best case scenario of the lowest possible cost for this test was assumed in computing the cost for algorithms involving use of Stat-Pak Dipstick.
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BMC Infectious Diseases

ISSN: 1471-2334

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