|
S/N
|
1st Assay
|
2nd Assay
|
Sensitivity % (95% CI)
|
Specificity % (95% CI)
|
Cost per algorithm (US$)
|
|---|
|
1
|
SD Bioline
|
First Response
|
100 (99.1–100)
|
99.9** (99.5–99.9)
|
0.47 + 0.65 = 1.12
|
|
2
|
First Response***
|
SD Bioline
|
99.5 (98.2–99.9)
|
100 (96–99.1)
|
0.65 + 0.47 = 1.12
|
|
3
|
SD Bioline
|
Determine
|
100 (99.1–100)
|
100* (96–99.1)
|
0.47 + 0.80 = 1.27
|
|
4
|
Determine
|
SD Bioline
|
100 (99.1–100)
|
100* (96–99.1)
|
0.80 + 0.47 = 1.27
|
|
5
|
SD Bioline
|
Stat-Pak Dipstick
|
100 (99.1–100)
|
100* (96–99.1)
|
0.47 + 0.80 = 1.27
|
|
6
|
Stat-Pak Dipstick***
|
SD Bioline
|
97.9 (96–99.1)
|
100 (96–99.1)
|
0.80 + 0.47 = 1.27
|
|
7
|
Determine
|
First Response
|
100 (99.1–100)
|
100* (96–99.1)
|
0.80 + 0.65 = 1.45
|
|
8
|
First Response***
|
Determine
|
99.5 (98.2–99.9)
|
99.9 (99.5–99.9)
|
0.65 + 0.80 = 1.45
|
|
9
|
First Response***
|
Stat-Pak Dipstick
|
99.5 (98.2–99.9)
|
100 (96–99.1)
|
0.65 + 0.80 = 1.45
|
|
10
|
Stat-Pak Dipstick***
|
First Response
|
97.9 (96–99.1)
|
100 (96–99.1)
|
0.80 + 0.65 = 1.45
|
|
11
|
Determine
|
Stat-Pak Dipstick
|
100 (99.1–100)
|
100* (96–99.1)
|
0.80 + 0.80 = 1.60
|
|
12
|
Stat-Pak Dipstick***
|
Determine
|
97.9 (96–99.1)
|
100 (96–99.1)
|
0.80 + 0.80 = 1.60
|
|
13
|
SD Bioline
|
Uni-Gold™
|
100 (99.1–100)
|
100* (96–99.1)
|
0.47 + 1.80 = 2.27
|
|
14
|
Uni-Gold™
|
SD Bioline
|
100 (99.1–100)
|
100* (96–99.1)
|
1.80 + 0.47 = 2.27
|
|
15
|
Uni-Gold™
|
First Response
|
100 (99.1–100)
|
100* (96–99.1)
|
1.80 + 0.65 = 2.45
|
|
16
|
First Response***
|
Uni-Gold™
|
99.5 (98.2–99.9)
|
100 (96–99.1)
|
0.65 + 1.80 = 2.45
|
|
17
|
Uni-Gold™
|
Stat-Pak Dipstick
|
100 (99.1–100)
|
100* (96–99.1)
|
1.80 + 0.80**** = 2.6
|
|
18
|
Stat-Pak Dipstick***
|
Uni-Gold™
|
97.9 (96–99.1)
|
100 (96–99.1)
|
0.80 + 1.80 = 2.60
|
|
19
|
Determine
|
Uni-Gold™
|
100 (99.1–100)
|
100* (96–99.1)
|
0.80 + 1.80 = 2.60
|
|
20
|
Uni-Gold™
|
Determine
|
100 (99.1–100)
|
100* (96–99.1)
|
1.80 + 0.80 = 2.60
|
- *Combination of the two assays had no concordant false positive results.
- **One sample was repeatedly concordantly false positive in the two assays.
- ***The first test had initial suboptimal sensitivity (< 100%).
- ****Cost of Stat-Pak Dipstick is indicated as a range 0.8–0.95 US$. The best case scenario of the lowest possible cost for this test was assumed in computing the cost for algorithms involving use of Stat-Pak Dipstick.
