Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania

Eligius F Lyamuya; Said Aboud; Willy K Urassa; Jaffer Sufi; Judica Mbwana; Faustin Ndugulile; Charles Massambu

doi:10.1186/1471-2334-9-19

BMC Infectious Diseases

Table 3 Sensitivity (n = 390), specificity (n = 1043) and cost of various combinations of rapid HIV assays

From: Evaluation of simple rapid HIV assays and development of national rapid HIV test algorithms in Dar es Salaam, Tanzania

S/N	1^st Assay	2^nd Assay	Sensitivity % (95% CI)	Specificity % (95% CI)	Cost per algorithm (US$)
1	SD Bioline	First Response	100 (99.1–100)	99.9** (99.5–99.9)	0.47 + 0.65 = 1.12
2	First Response***	SD Bioline	99.5 (98.2–99.9)	100 (96–99.1)	0.65 + 0.47 = 1.12
3	SD Bioline	Determine	100 (99.1–100)	100* (96–99.1)	0.47 + 0.80 = 1.27
4	Determine	SD Bioline	100 (99.1–100)	100* (96–99.1)	0.80 + 0.47 = 1.27
5	SD Bioline	Stat-Pak Dipstick	100 (99.1–100)	100* (96–99.1)	0.47 + 0.80 = 1.27
6	Stat-Pak Dipstick***	SD Bioline	97.9 (96–99.1)	100 (96–99.1)	0.80 + 0.47 = 1.27
7	Determine	First Response	100 (99.1–100)	100* (96–99.1)	0.80 + 0.65 = 1.45
8	First Response***	Determine	99.5 (98.2–99.9)	99.9 (99.5–99.9)	0.65 + 0.80 = 1.45
9	First Response***	Stat-Pak Dipstick	99.5 (98.2–99.9)	100 (96–99.1)	0.65 + 0.80 = 1.45
10	Stat-Pak Dipstick***	First Response	97.9 (96–99.1)	100 (96–99.1)	0.80 + 0.65 = 1.45
11	Determine	Stat-Pak Dipstick	100 (99.1–100)	100* (96–99.1)	0.80 + 0.80 = 1.60
12	Stat-Pak Dipstick***	Determine	97.9 (96–99.1)	100 (96–99.1)	0.80 + 0.80 = 1.60
13	SD Bioline	Uni-Gold™	100 (99.1–100)	100* (96–99.1)	0.47 + 1.80 = 2.27
14	Uni-Gold™	SD Bioline	100 (99.1–100)	100* (96–99.1)	1.80 + 0.47 = 2.27
15	Uni-Gold™	First Response	100 (99.1–100)	100* (96–99.1)	1.80 + 0.65 = 2.45
16	First Response***	Uni-Gold™	99.5 (98.2–99.9)	100 (96–99.1)	0.65 + 1.80 = 2.45
17	Uni-Gold™	Stat-Pak Dipstick	100 (99.1–100)	100* (96–99.1)	1.80 + 0.80**** = 2.6
18	Stat-Pak Dipstick***	Uni-Gold™	97.9 (96–99.1)	100 (96–99.1)	0.80 + 1.80 = 2.60
19	Determine	Uni-Gold™	100 (99.1–100)	100* (96–99.1)	0.80 + 1.80 = 2.60
20	Uni-Gold™	Determine	100 (99.1–100)	100* (96–99.1)	1.80 + 0.80 = 2.60

*Combination of the two assays had no concordant false positive results.
**One sample was repeatedly concordantly false positive in the two assays.
***The first test had initial suboptimal sensitivity (< 100%).
****Cost of Stat-Pak Dipstick is indicated as a range 0.8–0.95 US$. The best case scenario of the lowest possible cost for this test was assumed in computing the cost for algorithms involving use of Stat-Pak Dipstick.

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