Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study

Table 2 Infants who developed extra-renal dissemination of candidal infection from a cohort of 30 infants diagnosed with candiduria

Patient number	GA	Primary diagnosis	Extra-renal site	Species	Days between positive urine culture and positive culture at extra-renal site	Cultures performed between date of positive urine and date of positive culture at extra-renal site¹	Therapy between candiduria and positive culture at extra-renal site	Outcome of candidal infection	Treatment after diagnosis of extra-renal candidal infection
1	26 weeks	Prematurity	Blood	C. albicans	2	1 urine culture positive for C. albicans	None	Survived	32 days AMP, FCZ and 5FC in various combinations
2	28 weeks	Congenital heart disease	CNS (at autopsy)²	C. albicans	11	4 negative blood cultures	7 days AMP	Died	None
3	33 weeks	Congenital heart disease	Blood	C. parapsilosis	41	5 negative urine cultures³	13 days AMP	Survived⁴	28 days AMP and L-AMP
4	37 weeks	Congenital heart disease	Blood	C. albicans	32	5 urine cultures positive for C. albicans and 4 negative blood cultures	26 days AMP, FCZ or both⁵	Died	4 days L-AMP and FCZ

AMP - amphotericin B deoxycholate; CNS - central nervous system; FCZ - fluconazole; GA - gestational age; L-AMP- lipid-based amphotericin B; 5FC - 5 flucytosine
¹All had a negative blood culture on the day of diagnosis of candiduria
²Prior to the positive urine culture, had 7 negative blood cultures and 2 negative CSF cultures. Between the onset of candiduria and death had 4 negative blood cultures but cerebrospinal fluid not obtained
³ Blood culture was not performed initially or until 41 days after the date of the positive urine culture
⁴Ultimately died of congenital heart disease
⁵There was a 5-day gap after the first 5 days of therapy.

ISSN: 1471-2334