Figure 1

A-B-C. Long-term response to RD1 proteins in cured TB subjects and suspect of LTBI resulted negative to QFT-IT compared to healthy controls. IFN-γ production in response to RD1 proteins was evaluated at day 7 in diluted whole blood of subjects who resulted QFT-IT-negative as described in the material and method section. A) IFN-γ release was significantly higher in cured TB patients than healthy controls (p < 0.006). Horizontal lines indicate the median IFN-γ production. The data are presented as IU/mL. B). A ROC analysis was performed using the established cured TB group and the healthy controls group as comparator groups. C) IFN-γ production in response to RD1 proteins was higher, although not significantly, compared to controls (p < 0.06). Eleven out of thirty-six (30.6%) responded to RD1 proteins. Horizontal lines indicate the median IFN-γ production. The dotted line indicates the cut-off. The data are presented as IU/mL.