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Table 3 Changes in log10 levels of IL-8, TNF-α, NE and SLPI from pre-acquisition to acquisition, colonization and exacerbation samples. (p values by comparison to pre-acquisition levels by t test)

From: Moraxella catarrhalisacquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease

 

Acquisition-

Mean change (95% CI)

n = 76

Colonization samples only

Mean change (95% CI)

n = 34

Exacerbation samples only

Mean change (95% CI)

n = 42

Change in IL-8

0.39 (0.25-0.53)

(p =< 0.001)

0.23 (0.04-0.42)

(p = 0.015)

0.59 (0.38-0.79)

(p =< 0.001)

Change in TNF-α

0.72 (0.48-0.96)

(p =< 0.001)

0.58 (0.31-0.85)

(p =< 0.001)

0.89 (0.47-1.33)

(p =< 0.001)

Change in Elastase

1.12 (0.79- 1.44)

(p =< 0.001)

0.74 (0.32-1.16)

(p =< 0.001)

1.58 (1.08-2.08)

(p =< 0.001)

Change in SLPI

-0.51 (-0.72 to -0.30)

(p =< 0.001)

-0.47 (-0.72- -0.23)

(p =< 0.001)

-0.55 (-0.92- -0.19)

(p = 0.004)