Immune control of HIV-1 infection after therapy interruption: immediate versus deferred antiretroviral therapy

BMC Infectious Diseases

Table 1 Subjects with an immediate treatment of acute HIV-1 infection.

	ID	Age	Therapy†	Elapsed days‡	Days on therapy	At diagnosis*			At first interruption
						CD4	CD8	vRNA × 10⁴	CD4	CD8	vRNA
	Pt 03	19	D4T, 3TC, IDV	14	1775	653	1659	75	809	459	5794
	Pt 05	40	AZT, 3TC, IDV	61	1657	444	633	100	867	476	<50
	Pt 29	35	AZT, 3TC, NFV	14	1069	1103	1964	31	741	844	<50
	Pt 33	19	AZT, 3TC, IDV	66	925	424	991	0.13	458	474	147
Arm A	Pt 35	39	AZT, 3TC, EFV	1	1041	522	1205	78	919	607	496
	Pt 37	52	AZT, 3TC, EFV	0	1371	545	1233	3.9	901	384	<50
	Pt 58	26	AZT, 3TC, EFV	3	442	768	1632	50	1451	1580	<50
	Pt 06	24	AZT, 3TC, IDV	32	1620	882	4146	4.1	754	726	<50
	Pt 18	30	AZT, 3TC, IDV	26	635	1319	1810	15	1718	825	<80
	Pt 24	34	AZT, 3TC, IDV	3	1231	507	3162	78	513	1067	<50
	Pt 31	57	AZT, 3TC, EFV	19	1102	322	243	490	1154	1165	<50
Arm B	Pt 41	35	AZT, 3TC, EFV	12	705	568	278	130	1326	940	<50
	Pt 45	27	AZT, 3TC, EFV	5	488	307	1032	130	872	506	<50
	Pt 53	27	AZT, 3TC, Lop/rit	16	503	341	779	18.9	545	529	150
	Pt 04	25	AZT, 3TC, IDV	6	1561	603	1288	1.6	1047	1015	88
	Pt 19	41	AZT, 3TC, IDV	13	1480	1338	716	10	1113	447	<50
	Pt 28	25	AZT, 3TC, NFV	7	325	281	860	190	863	485	<80
	Pt 32	36	AZT, 3TC, EFV	15	1384	409	1448	4.3	960	331	<50
	Pt 72	20	AZT, 3TC, LPV	7	318	827	386	19	1005	751	<50
	Pt 81	33	AZT, 3TC, NVP	33	745	412	264	32.5	522	461	68
	Pt 85	27	AZT, 3TC, Lop/rit	46	717	326	669	50	855	1436	<50
	Pt 92	36	3TC, Lop/rit, TNF	0	455	616	3774	46.3	1027	913	<50

Clinical information about the twenty-two patients selected at the Clinical Department of the National Institute for Infectious Disease "L. Spallanzani" in Rome. All subjects received HAART within six months from primary infection.
†D4T, staduvine; 3TC, lamivudine; IDV, Indinavir; AZT, Zidovudine; NFV, nelfinavir; EFV, Efavirenz; NVP, nevirapine; TNF, Tenofovir; Lop, lopinavir; Rit, Ritonavir. ‡ Days elapsed from diagnosis (enrollment) to initiation of HAART. *CD4 and CD8 are per microlitre of plasma, viremia is per millilitre of plasma.

ISSN: 1471-2334