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Table 3 Risk of a validated medically attended local reaction following Td vaccination, by history of receipt of tetanus and diphtheria toxoid containing vaccinations1 in the prior five years, among persons with at least five years of enrollment in the MCO prior to the Td vaccination.

From: Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study

Age, years History of receipt of TDCV in five years prior to Td vaccination Number Td vaccinations Estimated number of local reactions2 Event risk (95% CI) per 10,000 Td vaccinations Incidence rate ratio (95% confidence interval) comparing those with and without a history of a TDCV in the prior five years
9-10 Yes 1,161 2 17.2 (2.9, 53.2) 4.6 (0.6, 35.4)
  No 8,015 3 3.7 (0.8, 17.2)  
11-15 Yes 2,876 2 8.2 (2.1, 32.6) 3.0 (0.8, 11.4)
  No 160,933 44 2.7 (1.8, 4.1)  
16-20 Yes 1,962 1 5.9 (0.8, 42.5) 1.8 (0.2, 15.6)
  No 27,713 9 3.3 (1.3, 8.2)  
21-25 Yes 165 0 0 Not estimable
  No 6,526 6 8.7 (3.1, 24.2)  
All Yes 6,164 6 9.0 (3.7, 22.2) 2.9 (1.2, 7.2)
  No 203,187 63 3.1 (2.2, 4.4)  
  1. CI = confidence interval
  2. 1 Includes Td vaccine as well as diphtheria, tetanus and pertussis vaccines administered as part of the childhood vaccination series.
  3. 2Based on multiple imputation; the total of the age-group specific estimates may not add up to the overall total due to rounding average values across imputed datasets.