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Table 2 Estimated risk of a validated medically attended local reaction by age at Td vaccination.

From: Frequency of medically attended adverse events following tetanus and diphtheria toxoid vaccine in adolescents and young adults: a Vaccine Safety Datalink study

Age group, years Number Td vaccinations Estimated1number of medically attended local reactions Estimated event risk (95% CI) per 10,000 Td vaccinations2
9-10 21,188 13 6.3 (3.4, 11.5)
11-15 310,803 88 2.8 (2.1, 3.7)
16-20 65,971 24 3.6 (2.3, 5.6)
21-25 38,866 34 8.7 (4.9, 15.7)
All 436,828 159 3.6 (2.8, 4.7)
  1. CI = confidence interval
  2. 1The number of events estimated based on multiple imputation applied to account for incomplete chart reviews.
  3. 2Compared with the 11-15 year old age group, the risk was significantly higher in the 9-10 year old age group (p = 0.01) and the 21-25 year old age group (p = 0.005). The risk among 21-25 year olds was also significantly higher than among 16-20 year olds (p = 0.01).