Skip to main content

Advertisement

Table 4 Sensitivity/specificity analysis using CD4 count thresholds, WHO clinical status, TB status, presence of ocular symptoms, presence of visual impairment

From: Prevalence of HIV-associated ophthalmic disease among patients enrolling for antiretroviral treatment in India: A cross-sectional study

Factor Number with HIV eye disease (n = 26) Number without HIV eye disease Sensitivity Specificity Positive predictive value Number needed to screen* (95%CI)
   (n = 123) (95% CI) (95% CI) (95% CI)  
WHO Clinical status       
Stage 1/2 2 58 7.7 (1.3-26.6) 52.8 (43.7-61.8) 3.3 (0.6-12.5) 30.3 (8-166.7)
Stage 3/4 24 65 92.3 (73.4-98.6) 47.2 (38.2-56.3) 27.0 (18.3-37.6) 3.7 (2.9-5.5)
TB status       
Past/current TB 19 60 73.1 (52.0-87.6) 51.2 (42.0-60.2) 24.1 (15.4-35.2) 4.1 (2.9-6.5)
CD4 count (cells/μL)       
≤ 50 7 6 27.0 (12.4-48.0) 95.1 (89.2-98.0) 53.8 (26.1-78.0) 1.9 (1.3-3.8)
≤ 100 13 23 50.0 (30.4-69.6) 81.3 (73.1-87.5) 36.1 (21.3-53.8) 2.8 (1.9-4.7)
≤ 150 18 41 69.2 (48.1-84.9) 66.7 (57.5-74.8) 30.5 (19.5-44.0) 3.3 (2.3-5.1)
≤ 200 20 64 76.9 (55.9-90.2) 48.0 (38.9-57.1) 23.9 (15.5-34.6) 4.2 (2.9-6.5)
≤ 250 22 89 84.6 (64.3-95.0) 27.6 (20.1-36.6) 19.8 (13.1-28.7) 5.1 (3.5-7.6)
Ocular symptoms       
Present 2 9 7.7 (4.0-13.2) 92.6 (86.1-96.3) 18.1 (3.2-52.2) 5.5 (1.9-31.2)
Vision status       
Visual impairment 5 7 20.0 (7.6-41.3) 94.0 (87.6-97.3) 41.7 (16.5-71.4) 2.4 (1.4-6.0)
  1. *The number needed to screen (NNS) is the number of people that need to be screened to detect one new case of eye disease