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Table 3 List of most significant canonical pathways overrepresented by upregulated genes in B. anthracis infected macrophages.

From: Gene expression profiling of human alveolar macrophages infected by B. anthracisspores demonstrates TNF-α and NF-κb are key components of the innate immune response to the pathogen

Ingenuity Canonical Pathways

P-value

Molecules

TREM1 signaling

0.00001

CCL3, ICAM1, IL18, NFKB1, NFKB2, TNF

Role of pattern recognition receptors in recognition of bacteria and viruses

0.00009

CCL5, NFKB1, NFKB2, NLRP3, PTX3, TNF

Acute Phase Response Signaling

0.0002

SOCS1, IL-18, IL-1α, SOD2, CP, NF-κB2, NF-κB1, TNF

IL-6 Signaling

0.0002

SOCS1, IL-18, IL-1α, NF-κB2, NF-κB1, TNF

Hepatic Cholestasis

0.0002

IL-18, IL-1α, ADCY4, NF-κB2, NF-κB1, TNF, IRAK2

p38 MAPK Signaling

0.0002

IL-18, IL-1α, TIFA, DUSP1, TNF, IRAK2

IL-10 Signaling

0.0003

IL-18, IL-1α, NF-κB2, NF-κB1, TNF