Table 4 Comparison of sensitivities and specificities of a selection of diagnostic real-time PCR assays for GBS (using culture for GBS as gold standard)
Reference | Assay name | Target gene | Sensitivity % (95% CI) | Specificity % (95% CI) |
|---|---|---|---|---|
This study | RiboSEQ GBS | ssrA | 96.4 (90.5 - 98.8) | 95.8 (84.6 - 99.3) |
Bergeron et al (2000) | Not specified | cfb | 97 (82.5 - 99.8) | 100 (94.2 - 100) |
Bergseng et al (2007) | Not specified | sip | 97 (90 - 99) | 99 (97 - 100) |
Davies et al (2004) | IDI-Strep B | cfb | 94 (90.1 - 97.8) | 95.9 (94.3 - 97.4) |
Gavino and Wang (2007) | GeneXpert GBS | cfb | 95.8 (76.9 - 99.8) | 64.5 (45.4 - 80.2) |
Uhl et al (2005) | LightCycler Strep B | ptsI | 100 (88.8 - 100) | 96.9 (92.2 - 99.1) |