Table 2 MTBDRplus-detected mutation frequency for RIF-R and INH-R on 63 MTB complex-positive samples, Burkina Faso
Smear result (no.) | GenoType® MTBDRplus | ||||
|---|---|---|---|---|---|
Drug susceptibility testing result | rpoB | katG | inhA | no. (%) | |
Positive (46) | MDR | D516V | S315T(1) | t-8c | 5 (10.8) |
D516V | S315T(1) | t-8a | 2 (4.3) | ||
D516V | S315T(1) | wt | 5 (10.8) | ||
H526D | S315T(1) | wt | 4 (8.7) | ||
H526D | S315T(2) | wt | 1 (2.2) | ||
H526Y | S315T(1) | t-8c | 2 (4.3) | ||
H526Y | S315T(1) | t-8a | 1 (2.2) | ||
H526Y | S315T(1) | wt | 2 (4.3) | ||
S531L | S315T(1) | c-15t | 1 (2.2) | ||
S531L | S315T(1) | wt | 1 (2.2) | ||
No wt 3–4–7 | S315T(1) | c-15t | 1 (2.2) | ||
No wt 7 | S315T(1) | wt | 3 (6.5) | ||
No wt 8 | S315T(1) | wt | 1 (2.2) | ||
RIF-R, INH-S | D516V | wt | wt | 1 (2.2) | |
S531L | wt | wt | 1 (2.2) | ||
RIF-S, INH-R | wt | S315T(1) | wt | 3 (6.5) | |
wt | S315T(1) | t-8a | 1 (2.2) | ||
RIF-S, INH-S | wt | wt | wt | 11 (23.9) | |
Negative (17) | MDR | D516V | S315T(1) | c-15t | 1 (5.8) |
RIF-S, INH-R | wt | S315T(1) | t-8a | 1 (5.8) | |
wt | S315T(1) | wt | 1 (5.8) | ||
RIF indeter, INH-S | indeter. | wt | wt | 1 (5.8) | |
RIF-S, INH-S | wt | wt | wt | 13 (76.5) | |