From: Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis
Sensitivity % (95% CI) |
Specificity % (95% CI) |
Positive predictive value % (95% CI) |
Negative predictive value % (95% CI) |
Positive diagnostic likelihood ratio (95% CI) |
Negative diagnostic likelihood ratio (95% CI) | ||
---|---|---|---|---|---|---|---|
Subgroup (n) | |||||||
LAM positivity in at least one out of two urine samples in combination with | |||||||
Lymphadenopathy | All (149) |
7.4 (2.4–16.3) |
98.8 (93.3–100.0) |
83.3 (35.9–99.6) |
55.9 (47.4–64.2) |
5.96 (0.71–49.80) |
0.94 (0.87–1.01) |
Body temperature ≥ 37.5°C | All (149) |
23.9 (14.3–35.9) |
98.8 (93.4–100.0) |
94.1 (71.3–99.9) |
61.4 (52.5–69.7) |
19.60 (2.67–144.0) |
0.77 (0.67–0.88) |
Fever* | All (150) |
44.9 (32.9–57.4) |
91.4 (83.0–96.5) |
81.6 (65.7–92.3) |
66.1 (56.5–74.7) |
5.20 (2.44–11.10) |
0.60 (0.48–0.75) |
Body weakness* | All (151) |
49.3 (37.0–61.6) |
89.0 (80.2–94.9) |
79.1 (64.0–90.0) |
67.6 (57.9–76.3) |
4.49 (2.32–8.70) |
0.57 (0.45–0.73) |
Chest pain* | All (151) |
50.7 (38.4–63.0) |
87.8 (78.7–94.0) |
77.8 (62.9–88.8) |
67.9 (58.2–76.7) |
4.16 (2.23–7.78) |
0.56 (0.44–0.72) |
Cough* | All (151) |
50.7 (38.4–63.0) |
87.8 (78.7–94.0) |
77.8 (62.9–88.8) |
67.9 (58.2–76.7) |
4.16 (2.23–7.78) |
0.56 (0.44–0.72) |
Expectoration* | All (151) |
47.8 (35.6–60.2) |
87.8 (78.7–94.0) |
76.7 (61.4–88.2) |
66.7 (56.9–75.4) |
3.92 (2.09–7.37) |
0.59 (0.47–0.76) |
Haemoptysis* | All (151) |
2.9 (0.4–10.1) |
98.8 (93.4–100.0) |
66.7 (9.4–99.2) |
54.7 (46.3–62.9) |
2.38 (0.22–25.70) |
0.98 (0.94–1.03) |
Loss of Appetite* | All (151) |
30.4 (19.9–42.7) |
95.1 (88.0–98.7) |
84.0 (63.9–95.5) |
61.9 (52.8–70.4) |
6.24 (2.25–17.30) |
0.73 (0.62–0.86) |
Night sweat* | All (151) |
46.4 (34.3–58.8) |
92.7 (84.8–97.3) |
84.2 (68.7–94.0) |
67.3 (57.8–75.8) |
6.34 (2.82–14.30) |
0.58 (0.46–0.73) |