Table 2 Diagnostic test performance of LAM-ELISA (groups A and B were defined as gold standard positives, Group C as negative controls, other groups with undefined TB status were excluded)
From: Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis
| Â | Â | Sensitivity % (95% CI) | Specificity % (95% CI) | Positive predictive value % (95% CI) | Negative predictive value % (95% CI) | Positive diagnostic likelihood ratio (95% CI) | Negative diagnostic likelihood ratio (95% CI) |
|---|---|---|---|---|---|---|---|
| Â | Subgroup (n) | Â | Â | Â | Â | Â | Â |
LAM positivity in at least one out of two urine samples | Â | Â | Â | Â | Â | Â | Â |
|  | All (151) | 50.7 (38.4–63.0) | 87.8 (78.7–94.0) | 77.8 (62.9–88.8) | 67.9 (58.2–76.7) | 4.16 (2.23–7.78) | 0.56 (0.44–0.72) |
|  | Females (79) | 66.7 (47.2–82.7) | 83.7 (70.3–92.7) | 71.4 (51.3–86.8) | 80.4 (66.9–90.2) | 4.08 (2.06–8.08) | 0.40 (0.24–0.67) |
|  | Males (72) | 38.5 (23.4–55.4) | 93.9 (79.8–99.3) | 88.2 (63.6–98.5) | 56.4 (42.3–69.7) | 6.35 (1.56–25.80) | 0.66 (0.50–0.85) |
|  | HIV-ve (64) | 21.1 (6.1–45.6) | 91.1 (78.8–97.5) | 50.0 (15.7–84.3) | 73.2 (59.7–84.2) | 2.37 (0.66–8.50) | 0.87 (0.68–1.11) |
|  | HIV+ve (87) | 62.0 (47.2–75.3) | 83.8 (68.0–93.8) | 83.8 (68.0–93.8) | 62.0 (47.2–75.3) | 3.82 (1.78–8.21) | 0.45 (0.31–0.66) |