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Table 2 Diagnostic test performance of LAM-ELISA (groups A and B were defined as gold standard positives, Group C as negative controls, other groups with undefined TB status were excluded)

From: Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis

   Sensitivity %
(95% CI)
Specificity
%
(95% CI)
Positive predictive value
%
(95% CI)
Negative predictive value
%
(95% CI)
Positive diagnostic likelihood ratio
(95% CI)
Negative diagnostic likelihood ratio
(95% CI)
  Subgroup (n)       
LAM positivity in at least one out of two urine samples        
  All
(151)
50.7
(38.4–63.0)
87.8
(78.7–94.0)
77.8
(62.9–88.8)
67.9
(58.2–76.7)
4.16
(2.23–7.78)
0.56
(0.44–0.72)
  Females (79) 66.7
(47.2–82.7)
83.7
(70.3–92.7)
71.4
(51.3–86.8)
80.4
(66.9–90.2)
4.08
(2.06–8.08)
0.40
(0.24–0.67)
  Males
(72)
38.5
(23.4–55.4)
93.9
(79.8–99.3)
88.2
(63.6–98.5)
56.4
(42.3–69.7)
6.35
(1.56–25.80)
0.66
(0.50–0.85)
  HIV-ve (64) 21.1
(6.1–45.6)
91.1
(78.8–97.5)
50.0
(15.7–84.3)
73.2
(59.7–84.2)
2.37
(0.66–8.50)
0.87
(0.68–1.11)
  HIV+ve (87) 62.0
(47.2–75.3)
83.8
(68.0–93.8)
83.8
(68.0–93.8)
62.0
(47.2–75.3)
3.82
(1.78–8.21)
0.45
(0.31–0.66)
  1. -ve = negative | +ve = positive