Transmission of Specific Genotype Streptomycin Resistant Strains of Mycobacterium tuberculosisin the Tokyo Metropolitan Area in Japan

Ohkado, Akihiro; Murase, Yoshiro; Mori, Masaaki; Hasegawa, Naoki; Otsuka, Goro; Nagamine, Michiko; Maeda, Hideo; Uchimura, Kazuhiro; Ohmori, Masako; Yamada, Norio; Maeda, Shinji; Kato, Seiya; Mori, Toru; Ishikawa, Nobukatsu

doi:10.1186/1471-2334-9-138

Table 1 Patient and VNTR Profiles whose M. tuberculosis Indicated M-strains

From: Transmission of Specific Genotype Streptomycin Resistant Strains of Mycobacterium tuberculosisin the Tokyo Metropolitan Area in Japan

No.	M-strain Type (*1)	Year Patient Registed	TB diagnosis (*2)	sex (*3)	Age (years old)	Internet-café use (*4)	Homeless (*5)	Drug Resistance (*6)	VNTR profiles (*7)
1	M5	2004	univ	M	22	No	No	SM	223315173533-42 5 3-884443 4 -4337
2	M5	2004	univ	M	22	No	No	SM	223315173533-42 5 3-884443 3 -4337
3	M5	2004	univ	M	22	No	No	SM	223315173533-42 5 3-884443 4 -4337
4	M5	2004	univ	M	22	Yes	No	SM	223315173533-42 5 3-884443 4 -4337
5	M5	2004	univ	F	21	No	No	SM	223315173533-42 5 3-884443 3 -4337
6	M5	2004	univ	M	22	No	No	SM	223315173533-42 5 3-884443 4 -4337
7	M5	2004	univ	M	22	No	No	SM	223315173533-42 5 3-884443 3 -4337
8	M5	2004	univ	M	22	No	No	SM	223315173533-42 5 3-884443 3 -4337
9	M5	2004	univ	M	22	No	No	SM & INH	223315173533-42 5 3-884443 4 -4337
10	M5	2004	univ	M	22	No	No	SM & INH	223315173533-42 5 3-884443 4 -4337
11	M5	2004	univ	M	22	No	No	SM	223315173533-42 5 3-88 2443 4 -4337
12	M5	2005	univ	F	unknown	No	No	SM	223315173533-42 5 3-884443 4 -4337
13	M5	2005	univ	M	22	No	No	SM	223315173533-42 5 3-884443 4 -4337
14	M5	2005	univ	M	24	No	No	SM	223315173533-42 5 3-884443 3 -4337
15	M5	2005	univ	M	21	No	No	SM	223315173533-42 5 3-884443 4 -4337
16	M5	2005	univ	M	22	No	No	SM	223315173533-42 5 3-884443 4 -4337
17	M5	2005	univ	M	23	No	No	SM	223315173533-42 5 3-884443 3 -4337
18	M5	2005	univ	M	22	No	No	SM	223315173533-42 5 3-884443 4 -4337
19	M5	2006	s	M	58	No	Yes	SM	223315173533-42 5 3-884443 3 -4337
20	M5	2007	s	M	39	Yes	Yes	SM	223315173533-42 5 3-884443 3 -4337
21	M4	2003	s	M	59	No	No	SM	223315173533-42 4 3-884443 3 -4337
22	M4	2004	univ	M	22	Yes	No	SM	223315173533-42 4 3-884443 3 -4337
23	M4	2004	univ	M	24	No	No	SM	223315173533-42 4 3-884443 3 -4337
24	M4	2004	Ob	M	24	No	No	SM	223315173533-42 4 3-884443 3 -4337
25	M4	2004	Ob	M	35	No	No	SM	223315173533-42 4 3-884443 3 -4337
26	M4	2004	ka	M	49	No	Yes	SM	223315173533-42 4 3-884443 3 -4337
27	M4	2004	ka	M	31	No	No	SM	223315173533-42 4 3-884443 3 -4337
28	M4	2004	ka	M	41	No	No	SM	223315173533-42 4 3-884443 3 -4337
29	M4	2004	s	M	65	Yes	Yes	SM	223315173533-42 4 3-884443 3 -4337
30	M4	2005	Ob(ka)	M	47	Yes	Yes	SM	223315173533-42 4 3-884443 3 -4337
31	M4	2005	Ob(s)	M	28	Yes	No	SM	223315173533-42 4 3-884443 3 -4337
32	M4	2005	Ob	M	31	Yes	Yes	SM	223315173533-42 4 3-884443 3 -4337
33	M4	2005	Ob	M	25	Yes	Yes	SM	223315173533-42 4 3-884443 3 -4337
34	M4	2005	ka	M	30	No	No	SM	223315173533-42 4 3-884443 3 -4337
35	M4	2005	ka	F	56	No	No	SM	223315173533-42 4 3-884443 3 -4337
36	M4	2005	ka	M	45	Yes	Yes	SM	223315173533-42 4 3-884443 3 -4337
37	M4	2006	ka	M	67	No	No	SM	223315173533-42 4 3-884443 3 -4337
38	M4	2006	ka	M	58	No	No	SM	223315173533-42 4 3-884443 3 -4337
39	M4	2006	s	F	33	No	No	SM	223315173533-42 4 3-884443 3 -4337
40	M4	2007	ka	M	46	No	No	SM	223315173533-42 4 3-884443 3 -4337
41	M4	2007	ka	M	54	No	No	SM	223315173533-42 4 3-884443 3 -4337
42	M4	2007	ka	M	44	No	No	SM	223315173533-42 4 3-684443 3 -4337
43	M4	2007	ka	F	39	No	No	SM	223315173533-42 4 3-884443 3 -4337
44	M4	2007	ka	M	55	No	No	SM	223315173533-42 4 3-884443 3 -4337
45	M4	2007	s	M	50	Yes	Yes	SM	223315173533-42 4 3-884443 3 -4337
46	M4	2007	s	M	45	No	Yes	SM	223315173533-42 4 3-884443 3 -4337

*1: "M4" indicates the M4-substrain with four tandem repeat copies at the ETR C locus. "M5" indicates the M5-substrain with five tandem repeat copies at the ETR C locus.
*2: "univ" indicates a TB patient detected through the contact investigation related to the tuberculosis outbreak at the university campus mentioned in the text.
"Ob" indicates a TB patient detected through contact investigations related to tuberculosis outbreak incidents other than the one at the university campus mentioned above.
"s" indicates a TB patient detected through the population-based DNA fingerprinting surveillance of M. tuberculosis in Shinjuku City.
"ka" indicates a TB patient detected through the hospital-based DNA fingerprinting surveillance of M. tuberculosis in Kawasaki City.
*3: "M" indicates male and "F" indicates female
*4: "Yes" indicates a TB patient who claimed to have a past history of the use of some internet cafés in the TMA within the past two years.
*5: A homeless person is defined as a person whose legal address is unknown or unstable at least within the past two years.
*6: Anti-tuberculosis agents the isolated M. tuberculosis indicated resistance. "SM" stands for Streptomycin, "INH" stands for Isoniazid.
*7: The 12 digits at the first part of the VNTR profile indicate the tandem repeat copy numbers according to the following loci set order: MIRU2, MIRU4, MIRU10, MIRU16, MIRU20, MIRU23, MIRU24, MIRU26, MIRU27, MIRU31, MIRU39, MIRU40 (Reference 5).
The 4 digits at the second part of the VNTR profile indicate the tandem repeat copy numbers according to the following loci set order: ETR A, ETR B, ETR C, ETR F (Reference 6).
The 7 digits at the third part of the VNTR profile indicate the tandem repeat copy numbers according to the following loci set order: QUB11b, QUB26, Mtub04, Mtub21, Mtub30, Mtub39, VNTR4156 (Reference 7).
The 4 digits at the last part of the VNTR profile indicate the tandem repeat copy numbers according to the following loci set order: QUB15, Mtub24, VNTR2372, VNTR3336 (Reference 8).

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ISSN: 1471-2334

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