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Table 8 Positive SeptiFast® and negative blood culture: Isolated Pathogens per Patient with positive SF and negative blood culture result

From: Clinical impact of a commercially available multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis

Pathogen Therapeutical relevance
Coagulase negative Staphylococci No change, empirical therapy sufficient and probable contamination
Enterococcus faecium No change, empirical therapy sufficient
Enterococcus faecium Modification necessary: Vancomycin added
Enterococcus faecium No change, empirical therapy sufficient
Enterococcus faecium, Klebsiella pneumoniae, Enterobacter cloacae/aerogenes No change, empirical therapy sufficient
Escherichia coli No change: patient deceased before results became available, empirical therapy sufficient
Candida krusei No change, empirical therapy sufficient
Streptococcus species No change, empirical therapy sufficient
Enterococcus faecium Modification necessary: Vancomycin added
Staphylococcus aureus No change, empirical therapy sufficient
Enterococcus faecium, Candida glabrata Modification necessary: Voriconazole added
Aspergillus fumigatus Modification necessary: Voriconazole added. Growth of colonies from broncho-alveolar-lavage Aspergillus-Ag elevated.
Candida albicans Modification necessary: Caspofungin added