Table 2 List of differentially expressed cell cycle genes >2 fold in early HCV relative to normal liver.
From: Modulations of cell cycle checkpoints during HCV associated disease
Gene Symbol | Average Ct Early HCV | Average Ct Normal | T-test p-value | Fold change |
|---|---|---|---|---|
Cell cycle progression/cell proliferation genes | ||||
MCM2 | 30.85 | 33.4 | 0.05 | 7.670 |
CDC2 | 32.5 | 34.15 | 0.36 | 4.79 |
MCM5 | 28.15 | 29.5 | 0.16 | 3.390 |
MCM3 | 28.0 | 29.1 | 0.11 | 3.100 |
CCNE1 | 33.6 | 34.9 | 0.05 | 4.76 |
CDK Inhibitors | ||||
CDKN1A | 27.5 | 28.2 | 0.258 | 2.24 |
CDKN1B | 27.65 | 28.6 | 0.034 | 2.36 |
G2/M checkpoint gene | ||||
GADD45A | 27.15 | 29.8 | 0.03 | 9.000 |
DNM2 | 31.75 | 29.6 | 0.005 | -2.65 |
KPNA2 | 31.3 | 29.25 | 0.169 | -3.730 |
Mitotic checkpoint genes | ||||
KNTC1 | 31.6 | 34.4 | 0.04 | 9.19 |
CKS1B | 31.0 | 33.5 | 0.17 | 7.200 |
MAD2L1 | 32 | 34.55 | 0.077 | 7.07 |
CDC34 | 30.0 | 31.3 | 0.35 | 3.4 |
CDC16 | 32.6 | 30.8 | 0.027 | -2.16 |
DNA damage response genes | ||||
CHEK1 | 32.35 | 33.70 | 0.24 | 3.09 |
HUS1 | 29.65 | 27.05 | 0.06 | -4.37 |
Cell cycle Regulators | ||||
HERC5 | 29.3 | 33.7 | 0.07 | 20.393 |
CCNG2 | 29.85 | 32.3 | 0.11 | 6.400 |
RBBP8 | 31.7 | 30 | 0.108 | -2.300 |
BCL2 | 29.65 | 31.60 | 0.052 | 3.10 |
UBE1 | 29.55 | 27.4 | 0.206 | -3.500 |