Figure 2

Overview of clinical structure of multi-HPV typemodel. HPV infection may progress to either genital warts or cervical disease, with regression possible for HPV infection, CIN grades 1–3 and genital warts. Treated genital warts, CIN and cervical cancer may result in disease eradication with elimination of HPV infection, disease eradication with persistent HPV infection, or failure to eradicate disease or HPV infection. Once CIN is detected, women are followed with annual Pap screening. Women in all health states are also subject to an age-specific rate of hysterectomy for benign conditions (not shown for simplicity). CIN = Cervical Intraepithelial Neoplasia; HPV = Human Papillomavirus.