Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs

Table 3 Significantly correlated pairs of mutations

Mutation 1	Frequency	Mutation 2	Frequency	Covariation Frequency	Phi^b	P-value ^c
	N (%)^a		N (%)^a	N (%)
RT
M41L	4 (1.9)	L210W	6 (2.8)	3 (1.4)	0.6	0.02
L210W	6 (2.8)	T215D	5 (2.3)	5 (2.3)	0.9	<0.001
L210W	6 (2.8)	K103N	7 (3.3)	3 (1.4)	0.4	0.04
T215D	6 (2.8)	V60I	34 (16.0)	5 (2.3)	0.3	0.02

^aThe frequency was determined in 213 HIV-1 B isolates from drug-naïve patients.
^bPositive correlations and negative correlations with phi >0.15 and phi <-0.07 are shown, respectively.
^cAll P values for covariation were significant at a false discovery rate of 0.05 following correction for multiple-hypothesis testing (Benjamini-Hochberg method).

ISSN: 1471-2334