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Table 1 Genotypic resistance results in 23 patients on ART with virological failure (HIV-1 RNA >1000 copies/mL)

From: Virological efficacy and emergence of drug resistance in adults on antiretroviral treatment in rural Tanzania

ID Sex Age ART regimen: initial (currenta) Months on ART Subtype Viral load Protease mutations Reverse transcriptase mutations
34 M 24 ZDV/3TC/NVP (ZDV/3TC/EFV) 42.1 C 434,131 M36I, L63P, H69K, I93L K103N
84 M 30 d4T/3TC/EFV (d4T/3TC/NVP) 49.1 D 8690 I13V, L33V, M36I, I64V K103N, M184V
224 M 32 d4T/3TC/NVP 34.7 C 1349 M36I, L63P, H69K, I93L  
240 M 43 d4T/3TC/EFV (d4T/3TC/NVP) 35.5 CRF01_AE 81,691 I13V, M36I, L63P, H69K D67N, K70R, K103N, V179T, M184V, K219Q
275 F 41 d4T/3TC/NVP 32.3 D 477,518 I13V, K20R, M36V, L63P, I64V, I93L G190A
282 F 32 d4T/3TC/NVP 32.4 A 2621 L10I, I13V, M36I, H69K M184V, Y188C
307 F 35 d4T/3TC/NVP (d4T/3TC/EFV) 31.7 Failed 2301 Failed Failed
321 F 34 d4T/3TC/NVP 30.4 D 1504 I13V, K20R, M36I, I62V, I64V Y181C, M184I
366 F 48 d4T/3TC/NVP 28.3 C 3000 M36I, H69K, I93L K103N, V179T, M184V
401 F 44 d4T/3TC/NVP 28.6 C 2290 M36I, D60E, H69K, I93L G190A
402 F 40 d4T/3TC/NVP (d4T/3TC/EFV) 28.3 ?b 20,500 L10I, I13V, G16E, M36I, H69K K101P, M184V, G190A, T215F
410 F 45 d4T/3TC/NVP 36.9 D 5990 I13V, L63P, I64V, V77I K101E, M184V, G190A
473 F 35 d4T/3TC/NVP 27.3 D 3965 I13V, I64V, V77I M41L, V75I, Y181C, M184V
476 F 19 ZDV/3TC/NVP (d4T/3TC/NVP) 26.5 D 1980 I64V G190A
516 F 24 d4T/3TC/EFV 24.0 C 419,979 M36I, L63P, H69K, I93L  
554 F 28 ZDV/3TC/NVP (d4T/3TC/NVP) 24.0 C 1886 K20R, M36I, H69K  
583 F 30 d4T/3TC/NVP 21.1 CRF01_AE 1432 L10V, G16E, M36IV, H69K K103N, Y181C, M184V
611 F 33 d4T/3TC/NVP 17.8 C 15,600 M36I, I62V, L63P, H69K, V82I, I93L K65R, V75I, V108I, Y181C, M184V, L210W
643 F 37 d4T/3TC/NVP 31.3 D 2400 K20R, M36I, I62V, I64M K70R, Y181C, M184V
749 F 32 d4T/3TC/EFV (d4T/3TC/NVP) 19.0 ?c 35,400 I13V, M36I, H69K K103N, M184V
752 F 35 d4T/3TC/NVP 14.5 A 3101 L10I, M36I, H69K Y181C, M184V
785 F 26 d4T/3TC/NVP (d4T/3TC/EFV) 14.6 D 3,683,117 I13V, M36I, D60E, I64V  
982 F 15 d4T/3TC/NVP 8.5 A 76,700 I13V, M36I, L63P, H69K, V82I V179T, M184V, G190A
  1. aOnly specified if different from initial regimen.bCRF_01AE in the protease and A in the reverse transcriptase gene. cA in the protease and CRF_01AE in the reverse transcriptase gene.
  2. ART, antiretroviral treatment; d4T, stavudine; 3TC, lamivudine; NVP, nevirapine; EFV, efavirenz; ZDV, zidovudine.