TY - JOUR AU - Poutanen, S. M. AU - Simor, A. E. PY - 2004 DA - 2004// TI - Clostridium difficile– associated diarrhea in adults JO - Can Med Assoc J VL - 171 UR - https://doi.org/10.1503/cmaj.1031189 DO - 10.1503/cmaj.1031189 ID - Poutanen2004 ER - TY - JOUR AU - Pepin, J. AU - Valiquette, L. AU - Alary, M. -. E. AU - Villemure, P. AU - Pelletier, A. AU - Forget, K. AU - Pepin, K. AU - Chouinard, D. PY - 2004 DA - 2004// TI - Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity JO - CMAJ VL - 17 UR - https://doi.org/10.1503/cmaj.1041104 DO - 10.1503/cmaj.1041104 ID - Pepin2004 ER - TY - JOUR AU - Voth, D. E. AU - Ballard, J. D. PY - 2005 DA - 2005// TI - Clostridium difficileToxins: Mechanism of action and role I disease JO - Clin Microbiol Rev VL - 18 UR - https://doi.org/10.1128/CMR.18.2.247-263.2005 DO - 10.1128/CMR.18.2.247-263.2005 ID - Voth2005 ER - TY - JOUR AU - Warny, M. AU - Pepin, J. AU - Fang, A. AU - Killgore, G. AU - Thompson, A. AU - Brazier, J. AU - Frost, E. AU - McDonald, L. C. PY - 2005 DA - 2005// TI - Toxin production by an emerging strain of Clostridium difficileassociated with outbreaks of severe disease in North America and Europe JO - Lancet VL - 366 UR - https://doi.org/10.1016/S0140-6736(05)67420-X DO - 10.1016/S0140-6736(05)67420-X ID - Warny2005 ER - TY - JOUR AU - McDonald, L. AU - Killgore, G. E. AU - Thompson, A. AU - Owens, R. C. AU - Kazakova, S. V. AU - Sambol, S. P. AU - Johnson, S. AU - Gerding, D. N. PY - 2005 DA - 2005// TI - An epidemic, toxin gene-variant strain of Clostridium difficile JO - N Engl J Med VL - 353 UR - https://doi.org/10.1056/NEJMoa051590 DO - 10.1056/NEJMoa051590 ID - McDonald2005 ER - TY - JOUR AU - Akerlund, T. AU - Svenungsson, B. AU - Lagergren, A. AU - Burman, L. G. PY - 2006 DA - 2006// TI - Correlation of disease severity with fecal toxin levels in patients with Clostridium difficile-associated diarrhea and distribution of PCR ribotypes and toxin yields in vitro of corresponding isolates JO - J Clin Microbiol VL - 44 UR - https://doi.org/10.1128/JCM.44.2.353-358.2006 DO - 10.1128/JCM.44.2.353-358.2006 ID - Akerlund2006 ER - TY - JOUR AU - Loo, V. G. AU - Poirier, L. AU - Miller, M. A. AU - Oughton, M. AU - Libman, M. D. AU - Micaud, S. AU - Bourgault, A. M. AU - Nguyen, T. AU - Frenette, C. AU - Kelly, M. AU - Vibien, A. AU - Brassard, P. AU - Fenn, S. AU - Dewar, K. AU - Hudson, T. J. AU - Horn, R. AU - Rene, P. AU - Monczaky Dascal, A. PY - 2005 DA - 2005// TI - A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality JO - N Engl J Med VL - 353 UR - https://doi.org/10.1056/NEJMoa051639 DO - 10.1056/NEJMoa051639 ID - Loo2005 ER - TY - JOUR AU - Pepin, J. AU - Valiquette, L. AU - Cossette, B. PY - 2005 DA - 2005// TI - Mortality attributable to nosocomial Clostridium difficile-associated disease furing an epidemic caused by a hypervirulent strain in Quebec JO - CMAJ VL - 173 UR - https://doi.org/10.1503/cmaj.050978 DO - 10.1503/cmaj.050978 ID - Pepin2005 ER - TY - JOUR AU - Miller, M. A. AU - Hyland, M. AU - Ofner-Agostini, M. AU - Gourdeau, M. AU - Ishak, M. PY - 2002 DA - 2002// TI - Morbidity, mortality, and healthcare burden of nosocomial Clostridium difficile-associated diarrhea in Canadian hospitals JO - Infect Control Hosp Epidemiol VL - 23 UR - https://doi.org/10.1086/502023 DO - 10.1086/502023 ID - Miller2002 ER - TY - JOUR AU - Soehn, F. AU - Wagenknecht-Wiesner, A. AU - Leukel, P. AU - Kohl, M. AU - Weidmann, M. AU - von eichel-Streiber, C. AU - Braun PY - 1998 DA - 1998// TI - Genetic rearrangements in the pathogenicity locus of Clostridium difficilestrain 8864 – implications for transcription, expression and enzymatic activity of toxins A and B JO - Mol Gen Genet VL - 258 UR - https://doi.org/10.1007/s004380050726 DO - 10.1007/s004380050726 ID - Soehn1998 ER - TY - JOUR AU - Gerding, D. N. AU - Johnson, S. AU - Peterson, L. R. AU - Mulligan, M. E. AU - Silva, J. PY - 1995 DA - 1995// TI - Clostridium difficile– associated diarrhea and colitis JO - Infect Control and Hosp Epidemiol VL - 16 UR - https://doi.org/10.2307/30141083 DO - 10.2307/30141083 ID - Gerding1995 ER - TY - JOUR AU - Spigaglia, P. AU - Mastrantonio, P. PY - 2004 DA - 2004// TI - Comparative analysis of Clostridium difficileclinical isolates belonging to different genetic lineages and time periods JO - J Med Microbiol VL - 53 UR - https://doi.org/10.1099/jmm.0.45682-0 DO - 10.1099/jmm.0.45682-0 ID - Spigaglia2004 ER - TY - JOUR AU - Stabler, R. A. AU - Gerding, D. N. AU - Songer, J. G. AU - Drudy, D. AU - Brazier, J. S. AU - Trinh, H. T. AU - Whitney, A. A. AU - Hinds, J. AU - Wren, B. W. PY - 2006 DA - 2006// TI - Comparative phylogenomics of Clostridium difficilereveals clade specificity and microevolution of hypervirulent strains JO - J Bacteriol VL - 188 UR - https://doi.org/10.1128/JB.00664-06 DO - 10.1128/JB.00664-06 ID - Stabler2006 ER - TY - JOUR AU - Cloud, J. AU - Kelly, C. P. PY - 2007 DA - 2007// TI - Update on Clostridium difficileassociated disease JO - Current Opinion in Gastroenterology VL - 23 ID - Cloud2007 ER - TY - JOUR AU - Hubert, B. AU - Loo, V. G. AU - Bourgault, A. M. AU - Poirier, L. AU - Dascal, A. AU - Fortin, E. AU - Dionne, M. AU - Lorange, M. PY - 2007 DA - 2007// TI - A portrait of the geographic dissemination of the Clostridium difficile North American Pulsed-Field Type 1 strain and the epidemiology of C. difficile-associated disease in Quebec JO - CID VL - 44 UR - https://doi.org/10.1086/510391 DO - 10.1086/510391 ID - Hubert2007 ER - TY - STD TI - Manitoba Monthly Communicable Disease Report. December 31. 2008, Publisher: Public Health Division, Public Health, Winnipeg, MB, Canada, [http://www.gov.mb.ca/health/publichealth/cdc/surveillance/index.html#reports] UR - http://www.gov.mb.ca/health/publichealth/cdc/surveillance/index.html#reports ID - ref16 ER - TY - JOUR AU - Chernak, E. AU - Johnson, C. C. AU - Weltman, A. AU - Wiggs, L. AU - Killgore, G. AU - Thompson, A. AU - LeMaile-Williams, M. AU - Lewis, F. M. PY - 2005 DA - 2005// TI - Severe Clostridium difficile-associated disease in populations previously at low risk – Four States 2005 JO - MMWR VL - 54 ID - Chernak2005 ER - TY - JOUR AU - Geric, B. AU - Rupnik, M. AU - Gerding, D. N. AU - Grabnar, M. AU - Johnson, S. PY - 2004 DA - 2004// TI - Distribution of Clostridium difficilevariant toxintypes and strains with binary toxin genes among clinical isolates in an American hospital JO - J MedMicrobiol VL - 53 ID - Geric2004 ER - TY - JOUR AU - Geric, B. AU - Johnson, S. AU - Gerding, D. N. AU - Brabnar, M. AU - Rupnik, M. PY - 2003 DA - 2003// TI - Frequency of binary toxin genes among Clostridium difficilestrains that do not produce large clostridial toxins JO - J Clin Microbiol VL - 41 UR - https://doi.org/10.1128/JCM.41.11.5227-5232.2003 DO - 10.1128/JCM.41.11.5227-5232.2003 ID - Geric2003 ER - TY - JOUR AU - MacCannell, D. R. AU - Louie, T. J. AU - Gregson, D. B. AU - Laverdiere, M. AU - Labbe, A. -. C. AU - Laing, F. AU - Henwick, S. PY - 2006 DA - 2006// TI - Molecular analysis of Clostridium difficilePCR ribotype 027 isolates from Eastern and Western Canada JO - J Clin Microbiol VL - 44 UR - https://doi.org/10.1128/JCM.02563-05 DO - 10.1128/JCM.02563-05 ID - MacCannell2006 ER - TY - JOUR AU - Stare, B. AU - Delmee, M. AU - Rupnik, M. PY - 2007 DA - 2007// TI - Variant Forms of the binary toxin CDT locus and tcdC gene in Clostridium difficilestrains JO - J Med Microbiol VL - 56 UR - https://doi.org/10.1099/jmm.0.46931-0 DO - 10.1099/jmm.0.46931-0 ID - Stare2007 ER - TY - JOUR AU - Chang, S. -. Y. AU - Song, K. -. P. PY - 2001 DA - 2001// TI - ADP-riobsylating binary toxin genes of Clostridium difficilestrain CCUG 20309 JO - DNA Sequence VL - 12 UR - https://doi.org/10.3109/10425170109047564 DO - 10.3109/10425170109047564 ID - Chang2001 ER - TY - JOUR AU - Goncalves, C. AU - Decre, D. AU - Barbut, F. AU - Burghoffer, B. AU - Petit, J. -. C. PY - 2004 DA - 2004// TI - Prevalence and characterization of a binary toxin (Actin-specific ADP-ribosyltransferase) from Clostridium difficile JO - J Clin Microbiol VL - 42 UR - https://doi.org/10.1128/JCM.42.5.1933-1939.2004 DO - 10.1128/JCM.42.5.1933-1939.2004 ID - Goncalves2004 ER - TY - JOUR AU - Terhes, G. AU - Urban, E. AU - Soki, J. AU - Hamid, K. A. AU - Nagy, E. PY - 2004 DA - 2004// TI - Community-acquired Clostridium difficilediarrhea caused by binary toxin, Toxin A and Toxin B gene-positive isolates in Hungary JO - J Clin Microbiol VL - 42 UR - https://doi.org/10.1128/JCM.42.9.4316-4318.2004 DO - 10.1128/JCM.42.9.4316-4318.2004 ID - Terhes2004 ER - TY - JOUR AU - Spigaglia, P. AU - Mastrantonio, P. PY - 2002 DA - 2002// TI - Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficileclinical isolates JO - J Clin Microbiol VL - 40 UR - https://doi.org/10.1128/JCM.40.9.3470-3475.2002 DO - 10.1128/JCM.40.9.3470-3475.2002 ID - Spigaglia2002 ER - TY - JOUR AU - Lemee, L. AU - Dhalluin, A. AU - Testelin, S. AU - Mattrat, M. -. A. AU - Maillard, K. AU - Lemeland, J. -. F. AU - Pons, J. -. L. PY - 2004 DA - 2004// TI - Multiplex PCR targeting tpi (triose phosphate isomerase), tcdA (toxin A), and tcdB (toxin B) genes for toxigenic culture of Clostridium difficile JO - J Clin Microbiol VL - 42 UR - https://doi.org/10.1128/JCM.42.12.5710-5714.2004 DO - 10.1128/JCM.42.12.5710-5714.2004 ID - Lemee2004 ER - TY - JOUR AU - Rupnik, M. AU - Dupuy, B. AU - Fairweather, N. F. AU - Gerding, D. N. AU - Johnson, S. AU - Just, I. AU - Lyerly, D. M. AU - Popoff, M. R. AU - Rood, J. I. AU - Sonenshein, A. L. AU - Thelestam, M. AU - Wren, B. W. AU - Wilkins, T. D. AU - von Eichel-Streiber, C. PY - 2005 DA - 2005// TI - Revised nomenclature of Clostridium difficiletoxins and associated genes JO - J Med Microbiol VL - 54 UR - https://doi.org/10.1099/jmm.0.45810-0 DO - 10.1099/jmm.0.45810-0 ID - Rupnik2005 ER - TY - JOUR AU - Stubbs, S. AU - Rupnik, M. AU - Gibert, M. AU - Brazier, J. AU - Duerden, B. AU - Popoff, M. PY - 2000 DA - 2000// TI - Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile JO - FEMS Microbiology Letters VL - 186 UR - https://doi.org/10.1111/j.1574-6968.2000.tb09122.x DO - 10.1111/j.1574-6968.2000.tb09122.x ID - Stubbs2000 ER - TY - JOUR AU - Alfa, M. J. AU - Swan, B. AU - VanDekerkhove, B. AU - Pang, P. AU - Harding, G. K. M. PY - 2002 DA - 2002// TI - The diagnosis of Clostridium difficile-associated diarrhea: comparison of Triage C. difficilepanel, EIA for Tox A/B and cytotoxin assays JO - Diagnostic Microbiology and Infectious Disease VL - 43 UR - https://doi.org/10.1016/S0732-8893(02)00413-3 DO - 10.1016/S0732-8893(02)00413-3 ID - Alfa2002 ER - TY - JOUR AU - Du, T. AU - Alfa, M. J. PY - 2004 DA - 2004// TI - Translocation of Clostridium difficiletoxin B across polarized Caco-2 cell monolayers is enhanced by toxin A JO - Canadian Journal of Infectious Disease VL - 15 UR - https://doi.org/10.1155/2004/292580 DO - 10.1155/2004/292580 ID - Du2004 ER - TY - JOUR AU - Grasset, E. AU - Pinto, M. AU - Dussaulx, E. AU - Zweibaum, A. AU - Desjeux, J. PY - 1984 DA - 1984// TI - Epithelial properties of human colonic carcinoma cell line Caco-2: Electrical parameters JO - Am J Physiol VL - 247 ID - Grasset1984 ER - TY - JOUR AU - Alfa, M. J. AU - Kabani, A. AU - Lyerly, D. AU - Moncrief, S. AU - Neville, L. M. AU - Al-Barrak, A. AU - Harding, G. K. H. AU - Dyck, B. AU - Olekson, K. AU - Embil, J. M. PY - 2000 DA - 2000// TI - Characterization of a toxin A-negative, toxinB-positive strain of Clostridium difficile responsible for a nosocomial outbreak of Clostridium difficile-associated diarrhea JO - J Clin Microbiol VL - 38 ID - Alfa2000 ER - TY - JOUR AU - Rupnick, M. AU - Braun, V. AU - Soehn, F. AU - Janc, M. AU - Hofsetter, M. AU - Laufenberg-Feldmann, R. AU - von Eichel-Streiber, C. PY - 1997 DA - 1997// TI - Characterization of polymprphisms in the toxin A and B genes of Clostridium difficile JO - FEMS Microbiology Letters VL - 148 UR - https://doi.org/10.1111/j.1574-6968.1997.tb10288.x DO - 10.1111/j.1574-6968.1997.tb10288.x ID - Rupnick1997 ER - TY - JOUR AU - Hundsberger, T. AU - Braun, V. AU - Weidmann, M. AU - Leukel, P. AU - Sauerborn, M. AU - von Eichel-Streiber, C. PY - 1997 DA - 1997// TI - Transcription analysis of the genes tcdA-E of the pathogenicity locus of Clostridium difficile JO - Eur J Biochem VL - 244 UR - https://doi.org/10.1111/j.1432-1033.1997.t01-1-00735.x DO - 10.1111/j.1432-1033.1997.t01-1-00735.x ID - Hundsberger1997 ER - TY - JOUR AU - Curry, S. R. AU - March, J. W. AU - Muto, C. A. AU - O'Leary, M. M. AU - Pasculle, A. W. AU - Harrison, L. H. PY - 2007 DA - 2007// TI - tcdC Genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile. JO - J Clin Microbiol VL - 45 UR - https://doi.org/10.1128/JCM.01599-06 DO - 10.1128/JCM.01599-06 ID - Curry2007 ER - TY - JOUR AU - Karlsson, S. AU - Dupuy, B. AU - Mukherjee, K. AU - Norin, E. AU - Burman Lars, G. AU - Akerlund, T. PY - 2003 DA - 2003// TI - Expression of Clostridium difficileToxins A and B and their Sigma Factor TcdD is controlled by temperature JO - Infect Immun VL - 71 UR - https://doi.org/10.1128/IAI.71.4.1784-1793.2003 DO - 10.1128/IAI.71.4.1784-1793.2003 ID - Karlsson2003 ER - TY - CHAP AU - Matamouros, S. AU - England, P. AU - Dupuy, B. PY - 2007 DA - 2007// TI - Clostridium difficiletoxin expression is inhibited by the novel regulator TcdC BT - Mol Microbiol ID - Matamouros2007 ER - TY - JOUR AU - Teichert, M. AU - Tatge, H. AU - Schoentaube, J. AU - Just, I. AU - Gerhard, R. PY - 2006 DA - 2006// TI - Application of mutated Clostridium difficileToxin a for determination of glycosyltransferase-dependent effect JO - Infect Immun VL - 74 UR - https://doi.org/10.1128/IAI.00545-06 DO - 10.1128/IAI.00545-06 ID - Teichert2006 ER - TY - CHAP AU - Freeman, J. AU - Baines, S. D. AU - Saxton, K. AU - Wilcos, M. H. PY - 2007 DA - 2007// TI - Effect of metronidazole on growth and toxin production by epidemic Clostridium difficilePCR ribotypes 01 and 027 in a human gut model BT - J Antimicrobial Chemotherapy ID - Freeman2007 ER - TY - JOUR AU - O'Connor, J. R. AU - Lyras, D. AU - Farrow, K. A. AU - Adams, V. AU - Powell, D. R. AU - Hinds, J. AU - Cheung, J. K. AU - Rood, J. I. PY - 2006 DA - 2006// TI - Construction and analysis of chromosomal Clostridium difficilemutants JO - Molec Microbiol VL - 61 UR - https://doi.org/10.1111/j.1365-2958.2006.05315.x DO - 10.1111/j.1365-2958.2006.05315.x ID - O'Connor2006 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/9/103/prepub UR - http://www.biomedcentral.com/1471-2334/9/103/prepub ID - ref41 ER -