Table 4 Piecewise exponential hazard regression model for factors associated with death in cases aged 18–64 years with invasive pneumococcal infection

Male sex

0.9

0.6–1.2

0.5

1.6

1.3–2.0

< 0.001

1.6

1.3–2.0

< 0.001

Age > 50 years

1.3

1.1–1.7

< 0.05

1.3

1.1–1.7

< 0.05

2.8

2.2–3.5

< 0.001

Meningitis

1.2

0.7–2.3

0.7

3.2

2.0–5.0

< 0.001

0.7

0.4–1.2

0.3

Alcohol-related diseases

5.6

3.8–8.1

< 0.001

3.8

2.9–4.9

< 0.001

3.8

2.9–4.9

< 0.001

Cardiac failure

2.6

1.8–3.8

< 0.001

2.6

1.8–3.8

< 0.001

2.6

1.8–3.8

< 0.001

Chronic renal failure

1.6

0.5–5.2

0.4

1.6

0.5–5.2

0.4

1.6

0.5–5.2

0.4

Chronic liver disease

4.4

2.3–8.6

< 0.001

4.4

2.3–8.6

< 0.001

4.4

2.3–8.6

< 0.001

HIV infection

4.8

2.1–10.9

< 0.001

4.8

2.1–10.9

< 0.001

4.8

2.1–10.9

< 0.001

Haematological malignancy^b

0.9

0.2–3.5

0.6

0.9

0.2–3.5

0.6

6.9

4.1–11.5

< 0.001

Non-haematological malignancy^b

4.7

3.3–6.7

< 0.001

4.7

3.3–6.7

< 0.001

4.7

3.3–6.7

< 0.001

Diabetes mellitus

1.4

0.9–2.0

0.13

1.4

0.9–2.0

0.13

1.4

0.9–2.0

0.13

Chronic pulmonary disease

1.0

0.6–1.6

1.0

1.0

0.6–1.6

1.0

1.0

0.6–1.6

1.0

Organ/bone marrow transplantation

0.9

0.4–1.8

0.7

0.9

0.4–1.8

0.7

0.9

0.4–1.8

0.7

Immunodeficiency/rheumatic diseases

1.7

1.2–2.2

< 0.05

1.7

1.2–2.2

< 0.05

1.7

1.2–2.2

< 0.05

Other^c medical underlying conditions

1.7

1.3–2.2

< 0.001

1.7

1.3–2.2

< 0.001

1.7

1.3–2.2

< 0.001

Healthy

Ref.^d

Ref.

Ref.