Skip to main content

Advertisement

Table 4 Piecewise exponential hazard regression model for factors associated with death in cases aged 18–64 years with invasive pneumococcal infection

From: Invasive pneumococcal infections among persons with and without underlying medical conditions: Implications for prevention strategies

  Death at 0–7 days Death at 8–28 days Death at 29–90 days
Factor Hazard ratio 95%CIa P-value Hazard ratio 95%CIa P-value Hazard ratio 95%CIa P-value
Male sex 0.9 0.6–1.2 0.5 1.6 1.3–2.0 < 0.001 1.6 1.3–2.0 < 0.001
Age > 50 years 1.3 1.1–1.7 < 0.05 1.3 1.1–1.7 < 0.05 2.8 2.2–3.5 < 0.001
Meningitis 1.2 0.7–2.3 0.7 3.2 2.0–5.0 < 0.001 0.7 0.4–1.2 0.3
Alcohol-related diseases 5.6 3.8–8.1 < 0.001 3.8 2.9–4.9 < 0.001 3.8 2.9–4.9 < 0.001
Cardiac failure 2.6 1.8–3.8 < 0.001 2.6 1.8–3.8 < 0.001 2.6 1.8–3.8 < 0.001
Chronic renal failure 1.6 0.5–5.2 0.4 1.6 0.5–5.2 0.4 1.6 0.5–5.2 0.4
Chronic liver disease 4.4 2.3–8.6 < 0.001 4.4 2.3–8.6 < 0.001 4.4 2.3–8.6 < 0.001
HIV infection 4.8 2.1–10.9 < 0.001 4.8 2.1–10.9 < 0.001 4.8 2.1–10.9 < 0.001
Haematological malignancyb 0.9 0.2–3.5 0.6 0.9 0.2–3.5 0.6 6.9 4.1–11.5 < 0.001
Non-haematological malignancyb 4.7 3.3–6.7 < 0.001 4.7 3.3–6.7 < 0.001 4.7 3.3–6.7 < 0.001
Diabetes mellitus 1.4 0.9–2.0 0.13 1.4 0.9–2.0 0.13 1.4 0.9–2.0 0.13
Chronic pulmonary disease 1.0 0.6–1.6 1.0 1.0 0.6–1.6 1.0 1.0 0.6–1.6 1.0
Organ/bone marrow transplantation 0.9 0.4–1.8 0.7 0.9 0.4–1.8 0.7 0.9 0.4–1.8 0.7
Immunodeficiency/rheumatic diseases 1.7 1.2–2.2 < 0.05 1.7 1.2–2.2 < 0.05 1.7 1.2–2.2 < 0.05
Otherc medical underlying conditions 1.7 1.3–2.2 < 0.001 1.7 1.3–2.2 < 0.001 1.7 1.3–2.2 < 0.001
Healthy Ref.d    Ref.    Ref.   
  1. aCI, confidence interval; b < 1 year since cancer diagnosis; cnon-PPV23 indication; dRef., reference