Table 2 Basic characteristics of healthcare-associated infections (HAIs) and of nosocomial fevers of unknown origin (nFUO)
Item | HAI (N = 263) | nFUO (N = 464) | P-value |
|---|---|---|---|
Number of patients included (in total, n = 411) | 181 | 230 | - |
Age at diagnosis of HAI/nFUO | < 0.001 | ||
< 5 years | 84 (32%) | 174 (38%) | |
5 years to < 10 years | 58 (22%) | 130 (28%) | |
10 years to < 15 years | 56 (21%) | 99 (21%) | |
≥ 15 years | 65 (25%) | 61 (13%) | |
Underlying disease | 0.07 | ||
Acute lymphoblastic leukemia | 86 (33%) | 136 (29%) | |
Acute myeloid leukemia | 34 (13%) | 40 (9%) | |
Lymphoma | 29 (11%) | 48 (10%) | |
solid tumor outside central nervous system | 70 (27%) | 166 (36%) | |
solid tumor of central nervous system | 34 (13%) | 65 (14%) | |
non-malignant hematologic disease | 10 (4%) | 9 (2%) | |
Relapse of malignancy | 54 (21%) | 68 (15%) | 0.049 |
Therapy§ preceding HAI/nFUO | 0.18 | ||
conventional chemotherapy | 214 (81%) | 391 (84%) | |
high-dose chemotherapy & autologous SCT | 22 (8%) | 44 (9%) | |
high-dose chemotherapy & allogeneic SCT | 26 (10%) | 25 (5%) | |
radiation therapy | 14 (5%) | 22 (5%) | |
Neutropenia at diagnosis of HAI/nFUO | 145 (55%) | 232 (50%) | 0.19 |