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Table 2 Basic characteristics of healthcare-associated infections (HAIs) and of nosocomial fevers of unknown origin (nFUO)

From: Healthcare-associated infections in pediatric cancer patients: results of a prospective surveillance study from university hospitals in Germany and Switzerland

Item HAI (N = 263) nFUO (N = 464) P-value
Number of patients included (in total, n = 411) 181 230 -
Age at diagnosis of HAI/nFUO    < 0.001
   < 5 years 84 (32%) 174 (38%)  
   5 years to < 10 years 58 (22%) 130 (28%)  
   10 years to < 15 years 56 (21%) 99 (21%)  
   ≥ 15 years 65 (25%) 61 (13%)  
Underlying disease    0.07
   Acute lymphoblastic leukemia 86 (33%) 136 (29%)  
   Acute myeloid leukemia 34 (13%) 40 (9%)  
   Lymphoma 29 (11%) 48 (10%)  
   solid tumor outside central nervous system 70 (27%) 166 (36%)  
   solid tumor of central nervous system 34 (13%) 65 (14%)  
   non-malignant hematologic disease 10 (4%) 9 (2%)  
Relapse of malignancy 54 (21%) 68 (15%) 0.049
Therapy§ preceding HAI/nFUO    0.18
   conventional chemotherapy 214 (81%) 391 (84%)  
   high-dose chemotherapy & autologous SCT 22 (8%) 44 (9%)  
   high-dose chemotherapy & allogeneic SCT 26 (10%) 25 (5%)  
   radiation therapy 14 (5%) 22 (5%)  
Neutropenia at diagnosis of HAI/nFUO 145 (55%) 232 (50%) 0.19
  1. Indicated are numbers (proportion of respective events).
  2. §Since more than one treatment modality was applicable, the numbers do not add up to 263 and 464, respectively.