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Table 4 Different approaches to routine screening with tuberculin skin test and QuantiFERON®TB Gold

From: Screening for tuberculosis infection among newly arrived asylum seekers: Comparison of QuantiFERON®TB Gold with tuberculin skin test

Screening programme approach Referral criteria Proportion (%) referred for treatment Proportion (%) LTBI* cases detected (detection rate) Proportion (%) non-infected referred for treatment (false positive rate)
Only TST TST ≥ 6 mm 50 89 42
  TST ≥ 10 mm 34 75 27
  TST ≥ 15 mm 15 47 0
Only QFT QFT positive 29 88 0
Two step (first TST, then QFT) TST ≥ 6 mm and QFT positive, or TST ≥15 mm 29 89 0
  TST ≥ 10 mm and QFT positive or TST ≥ 15 mm 25 75 0
  TST ≥ 15 mm (with or without QFT positives afterwards) 15 47 0
  1. *Latent infection is defined as either having a positive QuantiFERON(R)TB Gold test (264 participants) or a tuberculin skin test ≥15 mm and a negative QuantiFERON(R)TB Gold test (37 participants). Effect on screening based on identification of 301 cases of latent tuberculosis infection among 912 newly arrived asylum seekers in Norway Sept. 19. 2005 – June 12.2006