Table 3 Common variants in MBL2 and odds ratio for being HCV RNA negative among injection drug users
From: MBL2and Hepatitis C Virus Infection among Injection Drug Users
European Americans | African Americans | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Locus | Genotype | HCV RNA Negative | % | HCV RNA Positive | % | OR (95% CI) | HCV RNA Negative | % | HCV RNA Positive | % | OR (95% CI) |
T-1964C | |||||||||||
TT | 83 | 77.6 | 256 | 76.0 | 1.00 | 82 | 93.2 | 288 | 94.1 | 1.00 | |
TC | 23 | 21.5 | 73 | 21.7 | 0.94 (0.55–1.60) | 6 | 6.8 | 17 | 5.6 | 1.27 (0.48–3.36) | |
CC | 1 | 0.9 | 8 | 2.4 | 0.44 (0.05–3.51) | 0 | 0.0 | 1 | 0.3 | NA | |
TC + CC | 24 | 22.4 | 81 | 24.0 | 0.91 (0.54–1.53) | 6 | 6.8 | 18 | 5.9 | 1.20 (0.46–3.14) | |
G-618C (H/L) | |||||||||||
CC | 44 | 41.9 | 124 | 36.4 | 1.00 | 69 | 80.2 | 233 | 76.9 | 1.00 | |
CG | 47 | 44.8 | 164 | 48.1 | 0.80 (0.50–1.29) | 15 | 17.4 | 67 | 22.1 | 0.76 (0.41–1.42) | |
GG | 14 | 13.3 | 53 | 15.5 | 0.72 (0.36–1.43) | 2 | 2.2 | 3 | 1.0 | 2.63 (0.42–16.43) | |
CG + GG | 61 | 58.1 | 217 | 63.6 | 0.80 (0.51–1.26) | 17 | 19.8 | 70 | 23.1 | 0.83 (0.46–1.50) | |
G-289C (Y/X) | |||||||||||
GG | 59 | 55.1 | 218 | 66.3 | 1.00 | 63 | 71.6 | 218 | 70.6 | 1.00 | |
GC | 42 | 39.3 | 103 | 31.3 | 1.56 (0.98–2.49) | 23 | 26.1 | 87 | 28.2 | 0.92 (0.53–1.58) | |
CC | 6 | 5.6 | 8 | 2.4 | 2.72 (0.90–8.23) | 2 | 2.3 | 4 | 1.3 | 2.01 (0.35–11.42) | |
GC + CC | 48 | 44.9 | 111 | 33.7 | 1.65 (1.05–2.58) | 25 | 28.4 | 91 | 29.4 | 0.97 (0.57–1.63) | |
T-65C (P/Q) | |||||||||||
CC | 64 | 59.8 | 197 | 57.4 | 1.00 | 21 | 23.9 | 64 | 20.8 | 1.00 | |
CT | 38 | 35.5 | 127 | 37.0 | 0.93 (0.59–1.48) | 43 | 48.9 | 160 | 51.9 | 0.81 (0.44–1.48) | |
TT | 5 | 5.0 | 19 | 5.5 | 0.75 (0.27–2.09) | 24 | 27.3 | 84 | 27.3 | 0.85 (0.43–1.67) | |
CT + TT | 43 | 4.7 | 146 | 42.6 | 0.90 (0.58–1.40) | 67 | 76.1 | 244 | 79.2 | 0.83 (0.47–1.47) | |
Ex1 C-34T (D) | |||||||||||
CC | 95 | 87.2 | 300 | 87.5 | 1.00 | 87 | 97.8 | 303 | 98.1 | 1.00 | |
TC | 13 | 11.9 | 42 | 12.2 | 1.06 (0.54–2.10) | 2 | 2.3 | 6 | 1.9 | 1.11 (0.22–5.62) | |
TT | 1 | 0.9 | 1 | 0.3 | 2.71 (0.16–45.25) | 0 | 0.0 | 0 | 0.0 | NA | |
TC + TT | 14 | 12.8 | 43 | 12.5 | 1.00 (0.52–1.91) | 2 | 2.3 | 6 | 1.9 | 1.11 (0.22–5.62) | |
Ex1 G-27A (B) | |||||||||||
GG | 85 | 78.0 | 256 | 75.5 | 1.00 | 83 | 93.3 | 285 | 93.4 | 1.00 | |
GA | 23 | 21.1 | 75 | 22.1 | 0.90 (0.53–1.53) | 6 | 6.7 | 19 | 6.2 | 1.10 (0.42–2.86) | |
AA | 1 | 0.9 | 8 | 2.4 | 0.42 (0.05–3.46) | 0 | 0.0 | 1 | 0.3 | NA | |
GA + AA | 24 | 22.0 | 83 | 24.5 | 0.87 (0.52–1.46) | 6 | 6.7 | 20 | 6.6 | 1.04 (0.40–2.70) | |
Ex1 G-18A (C) | |||||||||||
GG | 95 | 92.2 | 312 | 96.0 | 1.00 | 49 | 56.3 | 168 | 55.6 | 1.00 | |
GA | 8 | 7.8 | 13 | 4.0 | 2.26 (0.89–5.73) | 29 | 33.3 | 116 | 38.4 | 0.86 (0.51–1.45) | |
AA | 0 | 0.0 | 0 | 0.0 | NA | 9 | 10.3 | 18 | 6.0 | 1.68 (0.71–3.99) | |
GA + AA | 8 | 7.8 | 13 | 4.0 | 2.26 (0.89–5.73) | 38 | 43.7 | 134 | 44.4 | 0.97 (0.60–1.57) | |
IVS2 G-630A | |||||||||||
GG | 22 | 20.8 | 59 | 17.9 | 1.00 | 49 | 57.6 | 168 | 54.4 | 1.00 | |
GA | 55 | 51.9 | 161 | 48.8 | 0.89 (0.50–1.59) | 31 | 36.5 | 127 | 41.1 | 0.84 (0.51–1.39) | |
AA | 29 | 27.4 | 110 | 33.3 | 0.68 (0.36–1.30) | 5 | 5.9 | 14 | 4.5 | 1.22 (0.41–3.60) | |
GA + AA | 84 | 79.3 | 271 | 82.1 | 0.82 (0.47–1.43) | 36 | 42.4 | 141 | 45.6 | 0.87 (0.54–1.42) | |
IVS2 T-250C | |||||||||||
TT | 42 | 40.4 | 119 | 35.6 | 1.00 | 72 | 80.9 | 236 | 76.9 | 1.00 | |
TC | 48 | 46.2 | 161 | 48.2 | 0.84 (0.52–1.36) | 15 | 16.9 | 68 | 22.2 | 0.73 (0.39–1.36) | |
CC | 14 | 13.5 | 54 | 16.2 | 0.72 (0.36–1.43) | 2 | 2.3 | 3 | 1.0 | 2.52 (0.40–15.75) | |
TC + CC | 62 | 59.6 | 215 | 64.4 | 0.83 (0.53–1.31) | 17 | 19.1 | 71 | 23.1 | 0.79 (0.44–1.43) | |
IVS3 G-28C | |||||||||||
GG | 72 | 66.7 | 239 | 70.7 | 1.00 | 36 | 41.9 | 135 | 43.8 | 1.00 | |
GC | 34 | 31.5 | 93 | 27.5 | 1.28 (0.79–2.07) | 39 | 45.3 | 144 | 46.8 | 1.02 (0.61–1.70) | |
CC | 2 | 1.9 | 6 | 1.8 | 0.98 (0.19–5.00) | 11 | 12.8 | 29 | 9.4 | 1.42 (0.65–3.14) | |
GC +CC | 36 | 33.3 | 99 | 29.3 | 1.25 (0.78–1.99) | 50 | 58.1 | 173 | 56.2 | 1.08 (0.66–1.76) | |
Ex4 C+5G | |||||||||||
GG | 70 | 66.7 | 244 | 71.6 | 1.00 | 41 | 46.1 | 143 | 46.6 | 1.00 | |
GC | 33 | 31.4 | 92 | 27.0 | 1.31 (0.81–2.14) | 39 | 43.8 | 138 | 45.0 | 0.98 (0.60–1.62) | |
CC | 2 | 1.9 | 5 | 1.5 | 1.17 (0.22–6.27) | 9 | 10.1 | 26 | 8.5 | 1.22 (0.53–2.82) | |
GC + CC | 35 | 33.3 | 97 | 28.4 | 1.32 (0.82–2.11) | 48 | 53.9 | 164 | 53.4 | 1.02 (0.63–1.64) | |
Ex4 T-1483C | |||||||||||
TT | 65 | 60.2 | 193 | 58.5 | 1.00 | 25 | 28.7 | 88 | 29.6 | 1.00 | |
TC | 36 | 33.3 | 117 | 35.5 | 0.91 (0.57–1.47) | 32 | 36.8 | 155 | 52.2 | 0.72 (0.40–1.30) | |
CC | 7 | 6.5 | 20 | 6.1 | 1.13 (0.45–2.83) | 30 | 34.5 | 54 | 18.2 | 2.02 (1.07–3.81) | |
TC + CC | 43 | 39.8 | 137 | 41.5 | 0.94 (0.60–1.47) | 62 | 71.3 | 209 | 70.4 | 1.05 (0.62–1.79) | |
Ex4 G-1067A | |||||||||||
GG | 18 | 17.5 | 46 | 13.8 | 1.00 | 62 | 72.9 | 199 | 65.9 | 1.00 | |
GA | 48 | 46.6 | 156 | 46.8 | 0.72 (0.38–1.37) | 19 | 22.4 | 92 | 30.5 | 0.67 (0.38–1.20) | |
AA | 37 | 35.9 | 131 | 39.3 | 0.65 (0.33–1.26) | 4 | 4.7 | 11 | 3.6 | 1.31 (0.40–4.32) | |
GA +AA | 85 | 82.5 | 287 | 86.2 | 0.70 (0.38–1.28) | 23 | 27.1 | 103 | 34.1 | 0.73 (0.43–1.25) | |
Ex4 G-901A | |||||||||||
AA | 61 | 58.1 | 187 | 57.0 | 1.00 | 26 | 29.2 | 90 | 29.8 | 1.00 | |
GA | 37 | 35.2 | 118 | 36.0 | 0.97 (0.60–1.55) | 35 | 39.3 | 160 | 53.0 | 0.75 (0.42–1.33) | |
GG | 7 | 6.7 | 23 | 7.0 | 1.02 (0.41–2.52) | 28 | 31.5 | 52 | 17.2 | 1.87 (0.99–3.53) | |
GA + GG | 44 | 41.9 | 141 | 43.0 | 0.69 (0.61–1.51) | 63 | 70.8 | 212 | 70.2 | 1.03 (0.61–1.73) | |
Ex4 G-710A | |||||||||||
AA | 65 | 60.7 | 196 | 58.3 | 1.00 | 18 | 20.2 | 65 | 21.3 | 1.00 | |
GA | 34 | 31.8 | 120 | 35.7 | 0.86 (0.54–1.39) | 34 | 38.2 | 150 | 49.2 | 0.82 (0.43–1.56) | |
GG | 8 | 7.5 | 20 | 6.0 | 1.31 (0.55–3.17) | 37 | 41.6 | 90 | 29.5 | 1.50 (0.78–2.88) | |
GA + GG | 42 | 39.3 | 140 | 41.7 | 0.92 (0.59–1.44) | 71 | 79.8 | 240 | 78.7 | 1.07 (0.60–1.93) | |