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Table 1 Blood cell parameters

From: Differential effects of antibiotics in combination with G-CSF on survival and polymorphonuclear granulocyte cell functions in septic rats

 

Control

G-CSF

PCI

coamoxiclav

coamoxiclav + G-CSF

Cef/met

Cef/met + G-CSF

WBC (10 6 cells/ml)

11.7 ± 0.9

22.7 ± 2.0#

8.0 ± 0.7

8.3 ± 0.6

9.6 ± 0.8

8.9 ± 0.7

10.7 ± 2.1

PMN (%)

16 ± 1.6

31 ± 3.5*

34 ± 3.5#

30 ± 4.6§

26 ± 3.7

37 ± 2.3#

35 ± 1.9#

  1. Blood cell parameters from naive and septic rats. Naive, non-infected control rats, naive rats treated with G-CSF only (20 μg/kg, 12 h before and 12 h after PCI), PCI rats without prophylaxis, PCI rats with antibiotic prophylaxis (coamoxiclav = CoA or ceftriaxone/metronidazole = Cef/met) and PCI rats with antibiotic plus G-CSF prophylaxis were analysed. Blood was sampled 24 h after PCI. Data are presented as means ± SEM from n = 9 animals/group. ANOVA analysis of variance revealed P < 0.001, df = 6 and post hoc tests of with Bonferroni correction obtained #P < 0.001 versus control, *P < 0.01 versus control, §P < 0.05 versus control.