| Control | G-CSF | PCI | coamoxiclav | coamoxiclav + G-CSF | Cef/met | Cef/met + G-CSF |
---|
WBC (10
6
cells/ml)
| 11.7 ± 0.9 | 22.7 ± 2.0#
| 8.0 ± 0.7 | 8.3 ± 0.6 | 9.6 ± 0.8 | 8.9 ± 0.7 | 10.7 ± 2.1 |
PMN (%)
| 16 ± 1.6 | 31 ± 3.5* | 34 ± 3.5#
| 30 ± 4.6§
| 26 ± 3.7 | 37 ± 2.3#
| 35 ± 1.9#
|
- Blood cell parameters from naive and septic rats. Naive, non-infected control rats, naive rats treated with G-CSF only (20 μg/kg, 12 h before and 12 h after PCI), PCI rats without prophylaxis, PCI rats with antibiotic prophylaxis (coamoxiclav = CoA or ceftriaxone/metronidazole = Cef/met) and PCI rats with antibiotic plus G-CSF prophylaxis were analysed. Blood was sampled 24 h after PCI. Data are presented as means ± SEM from n = 9 animals/group. ANOVA analysis of variance revealed P < 0.001, df = 6 and post hoc tests of with Bonferroni correction obtained #P < 0.001 versus control, *P < 0.01 versus control, §P < 0.05 versus control.