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Table 4 Vaccination effectiveness in those age 65 years and over (excluding very high risk) with equivalent number needed to vaccinate (NNV) estimates

From: The impact and effectiveness of pneumococcal vaccination in Scotland for those aged 65 and over during winter 2003/2004

Group

Number of vaccinated cases

Total number of cases

% Vaccination Effectiveness (95% CI)

Equivalent Number Needed to Vaccinate #(NNV) with 95% CI

Age 65+ years

    

   All

    

Crude

57

135

64.2 (49.6, 74.5)

-

Adjust

  

61.7 (45.1, 73.2)

5206 (4388, 7122)

(Age/Sex)

30

59

53.5 (22.5, 72.1)

6059 (4499, 14407)

   Male

27

76

71.1 (53.7, 81.9)

9835 (3987, 5944)

   Female

    

Age 65–74 years

    

   All

23

49

54.4 (20.1, 74.0)

9724 (7148, 26317)

   Male

13

24

41.0 (-31.7, 73.6)

(10726) §

   Female

10

25

64.6 (21.1, 84.1)

9835 (7554, 30110)

Age 75+ years

    

   All

34

86

68.8 (52.0, 79.8)

3145 (2712, 4162)

   Male

17

35

60.5 (23.3, 79.6)

3801 (2895, 9891)

   Female

17

51

73.9 (53.3, 85.4)

2836 (2454, 3932)

  1. * Vaccination effectiveness as determined by the screening method (see Methods)
  2. # NNV: number needed to vaccinate to prevent one case (calculated as 1/attributable risk; based on equivalent annual incidence of IPD in 2003/2004.
  3. §Hypothetical value for NNV given non-significant test result