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Table 5 Consolidation treatment used in different clinical studies

From: Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

Initial Treatment group Consolidation Treatment Follow-up period Study Identification/Year of Enrolment (Ref) Total patients
Artemether ir*, single dose Artemether ir 7 days Aceng 2002–3 [32] 51
Artemisinin ir, single dose Mefloquine + SP 72 hours Hien 1998 46
Artemisinin ir, multiple dose Mefloquine None post discharge Phuong 1992–5 [31] 46
    Vinh 1992–4 [33] 52
Artesunate ir, multiple dose Artesunate + SP 72 hours Karunajeewa 2003–4 [34] 41
  Mefloquine 28 days Looareesuwan 1995 [35] 60
    Than 1998 100
   None post discharge Bhatt 1994–5 [36] 23
  Chloroquine or SP None post discharge Karunajeewa 2001 [37] 48
Artesunate ir, single dose Artesunate + Mefloquine 28–42 days Van Vugt 1997–9 44
   28 days Looareesuwan 2000 69
  Mefloquine 28 days Looareesuwan 1996 26
  Chloroquine or SP 30 days Krishna 1996 [10] 23
  SP 28–42 days Molyneux 1997–8 [30] 113
  Mefloquine-SP 72 hours Hien 1998 44
Artesunate per os Artesunate + Mefloquine 28–42 days Van Vugt 1997–9 17
Artemisinins parenteral Artesunate + SP 72 hours Karunajeewa 2003–4 [34] 38
  Mefloquine 28 days Looareesuwan 1996 24
   None post discharge Phuong 1992–5 [31] 40
    Vinh 1992–4 [33] 123
  Chloroquine or SP 30 days Krishna 1996 [10] 11
Quinine parenteral Quinine 7 days Aceng 2002–3 [32] 52
  SP 28–42 days Barnes 1998 [30] 36
   None post discharge Phuong 1992–5 [31] 35
Quinine parenteral + Artesunate ir SP 42 days Barnes 1998 [30] 5
Grand Total     1167
  1. * ir: Intra-rectal