Skip to main content

Table 4 Parasite reduction ratio at 12 and 24 hours: Mixed model results

From: Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies

  12 hr final model 24 hour descriptive model** 24 hr final model
  % p-value N % p-value N Odds Ratio p-value N
Single Rectal Artemisinin or Artesunate vs Parenteral Artemisinins
Parenteral 45.7   225 83.8   49    179
Rectal 59.1 0.018 339 90.0 0.069 331 1.75* 0.072 201
Severe malaria 16.6 0.008        
Multiple Artesunate vs Single Artesunate
Single artesunate 57.7   169 93.7   80    155
Multiple artesunate 32.7 0.001 249 87.5 0.279 307 0.19 0.004 232
Total dose at 24 hours 19.5 0.011      1.14 0.008  
Single Artemisinin vs Single Artesunate
Single artesunate 64.2*   169 93.9   46    46
Single artemisinin 72.3 0.262 46 95.5 0.792 155 1.13* 0.813 155
Multiple Artemisinin vs Single Artemisinin
Single artemisinin 72.3   46 95.5   80    80
Multiple artemisinin 63.2 0.545 98 89.1 0.348 46 0.60* 0.403 46
Single Artemether vs Single Artesunate
Single artesunate 73.5   51 96.7   109    109
Single artemether 53.5 0.000 124 83.1 0.000 41 0.22* 0.002 41
  1. * No solution was found for the mixed model. Corresponding non-hierarchical regression used instead.
  2. ** Descriptive estimates of parasite reductions at 24 hours are provided only for comparisons with 12 hour estimates, see section 'Statistical analysis'